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Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Effect of long-acting polyethylene glycol recombinant human growth hormone dosages in pediatric practice: A pooled analysis of two phase IV randomized controlled trials. [PDF]

Chin Med J (Engl)
Hou L, Chen X, Du H, Zhang J, Cheng X, Pan J, Pan H, Liao W, Luo X, Fu J, 045 Study Group.   +10 more
europepmc   +1 more source

Evaluating the effect of recombinant human growth hormone treatment on sleep-related breathing disorders in toddlers with Prader-Willi syndrome: a one-year retrospective cohort study. [PDF]

BMC Pediatr
Guo H, Fu J, Zhou Y, Luo F, Cheng R.
europepmc   +1 more source

[Application and considerations of recombinant human growth hormone in treating growth disorders in children with chronic kidney disease]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Zhou JH.
europepmc   +1 more source

Recombinant human growth hormone therapy in a Chinese patient with trichorhinophalangeal syndrome I and growth hormone deficiency

Asian Journal of Surgery
Yujie Li, Ke Huang, Wei Wu, Guanping Dong   +3 more
doaj  

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Human Growth Hormone and Human Aging

Endocrine Reviews, 1993
In humans, both aging and GH deficiency are associated with reduced protein synthesis, decreased lean body and bone mass, and increased percent body fat. In healthy individuals, spontaneous and stimulated GH secretion, as well as circulating IGF-I and IGFBP-3 levels, are significantly decreased with advancing age.
S M Harman, E. Corpas, Marc R. Blackman
openaire   +4 more sources