Results 281 to 290 of about 1,273,047 (336)
American Journal of Diseases of Children, 1974 As recalled by Dr. Wilhelmi, it is now 30 years since Li, Evans, and Simpson conclusively demonstrated the existence of growth hormone (GH). Now, GH has an established place in the promotion of growth and the regulation of energy metabolism. In 1957 Daughaday discovered a serum factor ("sulfation factor" or somatomedin [SM]) that, under the influence ...
Noel K. Maclaren +2 more
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Pharmacological Reviews, 1988
The study of human growth hormone is a little more than 100 years old. Growth hormone, first identified for its dramatic effect on longitudinal growth, is now known to exert generalized effects on protein, lipid, and carbohydrate metabolism. Additional roles for growth hormone in human physiology are likely to be discovered in the areas of sleep ...
M J Thomas, Jeannine S. Strobl
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The study of human growth hormone is a little more than 100 years old. Growth hormone, first identified for its dramatic effect on longitudinal growth, is now known to exert generalized effects on protein, lipid, and carbohydrate metabolism. Additional roles for growth hormone in human physiology are likely to be discovered in the areas of sleep ...
M J Thomas, Jeannine S. Strobl
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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 1992Binding of human growth hormone (hGH) to its receptor is required for regulation of normal human growth and development. Examination of the 2.8 angstrom crystal structure of the complex between the hormone and the extracellular domain of its receptor ...
A. D. Vos, M. Ultsch, A. Kossiakoff
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New England Journal of Medicine, 1989
In a double-blind, placebo-controlled trial, we studied the effects of six months of growth hormone replacement in 24 adults with growth hormone deficiency.
F. Salomon +3 more
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In a double-blind, placebo-controlled trial, we studied the effects of six months of growth hormone replacement in 24 adults with growth hormone deficiency.
F. Salomon +3 more
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Journal of Clinical Oncology, 2018
Purpose This phase III study evaluated ribociclib plus fulvestrant in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer who were treatment naïve or had received up to one line of prior ...
D. Slamon +20 more
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Purpose This phase III study evaluated ribociclib plus fulvestrant in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer who were treatment naïve or had received up to one line of prior ...
D. Slamon +20 more
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Antibodies to human growth hormone developing during therapy with human growth hormone
The Journal of Pediatrics, 1965THE DETECTION of antibodies to human growth hormone (HGH) developing during long-term therapy with HGH has recently been reported by several investigators. Antibodies did not appear to interfere with the response to HGH in two patients reported by Trafford et al1or in three patients reported by Roth et al.2The growth-promoting effect appeared to be ...
Fred G. Smith, S. Douglas Frasier
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Science, 1991
Human growth hormone (hGH) forms a 1:2 complex with the extracellular domain of its receptor-binding protein (hGHbp) as studied by crystallization, size exclusion chromatography, calorimetry, and a previously undescribed fluorescence quenching assay ...
B. Cunningham +5 more
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Human growth hormone (hGH) forms a 1:2 complex with the extracellular domain of its receptor-binding protein (hGHbp) as studied by crystallization, size exclusion chromatography, calorimetry, and a previously undescribed fluorescence quenching assay ...
B. Cunningham +5 more
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Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
Science, 1982A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val ...
R. Guillemin +5 more
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Human pituitary growth hormone
Experientia, 1964Aus Tierexperimenten mit Wachstumshormonen aus Rindern wird klar, dass das Hormon eine Anzahl anderer biologischer Funktionen ausubt als seine wachstumsfordernde Tatigkeit. Im Menschen hat sich das Wachstumshormon als starkstes anabolisches Agens der bisher untersuchten Arzneimittel oder Hormone erwiesen.
Choh Hao Li, Wan-Kyng Liu
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The Journal of Pediatrics, 1960
Summary A “hypopituitary” dwarf was treated during a 10-month period with human growth hormone (Raben12); there was a resultant spurt in growth associated with relatively slight, if any, maturation in body proportions and skeleton. Radiologic evidence of widening of the epiphyseal plates was noted.
Sorrel Waxman +3 more
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Summary A “hypopituitary” dwarf was treated during a 10-month period with human growth hormone (Raben12); there was a resultant spurt in growth associated with relatively slight, if any, maturation in body proportions and skeleton. Radiologic evidence of widening of the epiphyseal plates was noted.
Sorrel Waxman +3 more
openaire +2 more sources