Results 161 to 170 of about 4,102,561 (300)

Characterization of miRNA profiling in konjac-derived exosome-like nanoparticles and elucidation of their multifaceted roles in human health [PDF]

Chuan Shen, Xia Li, Jianfeng Qin, Longfei Duan   +3 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Erratum: Correction: The impact of perfumes and cosmetic products on human health: a narrative review. [PDF]

Front Toxicol
Alblooshi S.
europepmc   +1 more source

A protocol for a systematic review and meta-analysis of the health and healthcare system burden due to human Escherichia coli infections resistant to third/fourth/fifth generation cephalosporins or quinolones, or with multidrug resistance

, 2019
Melissa C. MacKinnon, Jan M. Sargeant, David L. Pearl, Richard J. Reid‐Smith, Carolee A. Carson, E. Jane Parmley, Scott A. McEwen   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Role of Ion Channels and Transporters in Human Health and Diseases. [PDF]

Biomedicines
Soda T.
europepmc   +1 more source

Study Guide for Memmler's The Human Body in Health and Disease

, 2018
Barbara J. Cohen, Kerry Hull
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dietary Selenium-Enriched Aquatic Products for Human Health. [PDF]

Nutrients
Qiu H, Ren H, Wang W, Huang J, Wang L, Jin X.   +5 more
europepmc   +1 more source

Regulating mercury with the Clear Skies Act : the resulting impacts on innovation, human health, and the global community

, 2006
Meghan Sweeney
openalex   +1 more source