Results 61 to 70 of about 4,102,561 (300)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
PharmaceuticsThe development of resistance to traditional antifungal therapies has necessitated the exploration of alternative treatment strategies to effectively manage fungal infections, particularly those induced by Candida albicans (C. albicans).
Atif Ullah +7 more
doaj +1 more source
A proof-of-concept online metadata catalogue service of Earth observation datasets for human health research in exposomics [PDF]
, 2023 Keumseok Koh +6 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020 Pharmaceutical specialist, in accordance with professional standards and federal state educational standards of higher education should be able to organize and conduct outreach work to promote a healthy lifestyle and rational use of drugs.
I. Yu. Nefedov, I. Yu. Nefedovа
doaj
Climate change, air pollution and human health in Sydney, Australia: A review of the literature
Environmental Research Letters, 2018 Sydney is Australia’s largest city and is growing rapidly. Although Sydney’s air quality is relatively good compared to the major cities in many industrialised countries, particulate matter (PM) and ozone (O _3 ) occasionally exceed the national health ...
Annika Dean, Donna Green
doaj +1 more source
Human health cost of hydrogen sulfide air pollution from an oil and gas Field
Annals of Agricultural and Environmental Medicine, 2017 Introduction and objective The Karachaganak oil and gas condensate field (KOGCF), one of the largest in the world, located in the Republic of Kazakhstan (RoK) in Central Asia, is surrounded by 10 settlements with a total population of 9,000 people ...
Dinara Kenessary +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Environmental Research Letters, 2018 Throughout the Euro-Arctic region of Russia (Murmansk region), there is a substantial increase of metal concentrations in water, which are related to local discharges from the metallurgical and mining industry, transboundary pollution, as well as ...
T I Moiseenko +4 more
doaj +1 more source