Results 131 to 140 of about 18,164,503 (309)

Inventory update 00 : a regional analysis of health personnel in the province of British Columbia [PDF]

, 2001
The Cooperative Health Human Resources Database (CHHRD), developed and maintained by the Health Human Resources Unit (HHRU) since 1973, provides the basis for a number of our regular and special reports.
University of British Columbia. Health Human Resources Unit
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Human health risk of toxic chemical pollutants generated from traffic and land use activities [PDF]

, 2016
The research project developed a quantitative approach to assess the risk to human health from heavy metals and polycyclic aromatic hydrocarbons in urban stormwater based on traffic and land use factors.
Ma, Yukun
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The potential impact of nano- and microplastics on human health: Understanding human health risks.

Environmental Research
Plastics are used all over the world. Unfortunately, due to limited biodegradation, plastics cause a significant level of environmental pollution. The smallest recognized to date are termed nanoplastics (1 nm [nm] up to 1 μm [μm]) and microplastics (1 μm-5 mm).
Ewa Winiarska, Marek Jutel, Magdalena Zemelka-Wiacek   +2 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Influence of Urban Land Surface Temperature on Heavy Metal Accumulation in Cabbage and Lettuce Across the Greater Accra Metropolitan Area

Resources
This study assessed the concentrations and health risks of heavy metals in cabbage (Brassica oleracea) and lettuce (Lactuca sativa) cultivated across three urban land surface temperatures in the Greater Accra Metropolitan Area (GAMA): Atomic (low land ...
Joyce Kumah, Benedicta Yayra Fosu-Mensah, Benjamin Dankyira Ofori, Millicent A. S. Kwawu, Christopher Gordon   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Depth Distribution of Microplastics Contamination and Associated Risks in Homestead Farming Soils from Industrial and Non-Industrial Regions of Bangladesh

Micro
Microplastic (MP) contamination in terrestrial ecosystems has emerged as a critical environmental concern, particularly in agricultural soils influenced by anthropogenic activities. This study investigated the depth-wise distribution, polymer composition,
Afia Sultana, Qingyue Wang, Miho Suzuki, Christian Ebere Enyoh, Md. Sohel Rana, Weiqian Wang, Anunobi Chinazo Ndidiamaka   +6 more
doaj   +1 more source