Results 221 to 230 of about 18,164,503 (309)

On the brink: H5N1 and the risk to human health

The Lancet Regional Health - Americas
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Current-use and legacy pesticides in canal waters of Chiang Mai, Thailand, during longan flowering and fruit set: occurrence and ecological and human health risk assessment. [PDF]

Sci Rep
Udomkun P, Rupngam T, Graham M, Boonupara T, Kaewlom P.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Aflatoxin M1 in Milk and Dairy Products in Birjand, Iran: A Contribution to Human Health Risk Assessment. [PDF]

Food Sci Nutr
Ebadi Fathabad A, Zarghi MH, Jahed Khaniki G, Shariatifar N, Johari N, Yousefi S, Aslani R.   +6 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Neurodevelopmental effects of methylmercury (MeHg): a review of epidemiological points of departure (PoDs), toxicological reference values (TRVs), and key uncertainties in human health risk assessment. [PDF]

Arch Toxicol
Blechinger SR, Singh K, Afghan A, Smith CA.   +3 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Human Health Risk Assessment from the Tilapia Fish in Heavy Metal-Contaminated Landfill Reservoir. [PDF]

Int J Environ Res Public Health
Yang N, Monkheang P, Neeratanaphan L, Intamat S, Tengjaroensakul B.   +4 more
europepmc   +1 more source

HUMAN HEALTH IN A RISK SOCIETY

, 2019
Lydiia Gazniuk, Yuliia Semenova
openaire   +1 more source