Results 171 to 180 of about 145,693 (256)
ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang +6 more
wiley +1 more source
Clinical characteristics and prognostic analysis of patients with herpesvirus meningitis/encephalitis based on cerebrospinal fluid mNGS positivity. [PDF]
Yang H, Zhao L.
europepmc +1 more source
Utility and clinical relevance of multiplex PCR panels for diagnosis of central nervous system infections. [PDF]
Gürler M +4 more
europepmc +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
Herpes B virus and the neglected risk of zoonotic spillover. [PDF]
Kim Y, Lee JM, Hong JJ.
europepmc +1 more source
Objective Sjögren's disease (SjD) is a chronic autoimmune disease with a complex etiology, where pathogens may influence disease development or progression. Although SjD is not communicable, environmental and endemic pathogen exposures may influence its onset or progression.
Swetha K. Shankar +3 more
wiley +1 more source
Acute retinal necrosis: Report 1-Epidemiology, clinical profile, and misdiagnosis from the largest Indian case series. [PDF]
Priyadarshini S +7 more
europepmc +1 more source
Portable Molecularly Imprinted Polymer Sensor for Rapid Swab‐Based Detection of Norovirus
This work reports a rapid, portable smartphone‐based sensor capable of detecting four norovirus genotypes from swab samples within 15 min. Sensor selectivity was validated through evaluation against four common live viruses. The swab‐based sampling process enabled simple sample preparation combined with the compact detection system, supporting use of ...
Amy Dann +13 more
wiley +1 more source
Clinical features and outcomes of herpes simplex viral infections with co-infection in 100 children. [PDF]
Wang P, Li J.
europepmc +1 more source
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source

