Results 81 to 90 of about 172,224 (286)

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core  

EHV-1 Pathogenesis: Current in vitro Models and Future Perspectives [PDF]

, 2019
Primary infection and pathogenesis of equine herpesvirus type 1 (EHV-1) require an intricate interaction of virus with the mucosal epithelium, mononuclear cells and the vascular endothelium.
Azab, Walid, Kamel, Mohamed, Osterrieder, Klaus, Pavulraj, Selvaraj   +3 more
core   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

Biotechnology Progress, EarlyView.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao, Ronny Horax, Xianghong Qian, April Wheeler, Hironobu Shirataki, S. Ranil Wickramasinghe   +5 more
wiley   +1 more source

Animal models of human herpesvirus infection

Animal Models and Experimental Medicine
Human herpesvirus, a specific group within the herpesvirus family, is responsible for a variety of human diseases. These viruses can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby ...
Ziqing Jia, Dong Zhang, Lin Zhu, Jing Xue   +3 more
doaj   +1 more source

Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture [PDF]

Journal of Clinical Microbiology, 1990
The SF strain of human herpesvirus 6 (HHV-6SF) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged
Jay A. Levy, Alan L. Landay, Evelyne T. Lennette   +2 more
openaire   +3 more sources

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source

Animal herpesviruses and their zoonotic potential for cross-species infection

Annals of Agricultural and Environmental Medicine, 2015
Herpesviruses of humans and animals cause severe diseases that influence not only the health and epidemiological status but are also economically important in the context of food production. The members of Herpesviridae are host specific agents that also
Grzegorz Woźniakowski, Elżbieta Samorek-Salamonowicz   +1 more
doaj   +3 more sources

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Calendar, R., Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Gold, L., Jahn, Gerhard, Rüger, Rüdiger, Schaffner, Walter, Stoerker, Jay, Weber, Frank   +9 more
core   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Usefulness of Herpes Consensus PCR methodology to routine diagnostic testing for herpesviruses infections in clinical specimens

Virology Journal, 2007
The purposes of the study were to assess the usefulness of simultaneously amplifying herpes simplex virus 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and human herpesvirus 6 DNA in various clinical specimens and to analyze ...
Priavali Efthalia, Gartzonika Constantina, Kalogeropoulos Christos, Vrioni Georgia, Levidiotou Stamatina   +4 more
doaj   +1 more source