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The genome of herpesvirus papio 2 is closely related to the genomes of human herpes simplex viruses
Infection of baboons (Papio species) with herpesvirus papio 2 (HVP-2) produces a disease that is clinically similar to herpes simplex virus (HSV-1 and HSV-2) infection of humans. The development of a primate model of simplexvirus infection based on HVP-2 would provide a powerful resource to study virus biology and test vaccine strategies.
John E. Bigger, David W. Martin
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Review part 2: Human herpesvirus‐6 in central nervous system diseases [PDF]
AbstractJ. Med. Virol. 82:1669–1678, 2010. © 2010 Wiley‐Liss, Inc.
Karen Yao+4 more
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Cercopithecine herpesvirus 1 (monkey B virus; BV) produces extremely severe and usually fatal infections when transmitted from macaque monkeys to humans. Cercopithecine herpesvirus 16 (herpesvirus papio 2; HVP2) is very closely related to BV, yet cases of human HVP2 infection are unknown.
Kristin M. Rogers+4 more
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Arginine inactivates human herpesvirus 2 and inhibits genital herpesvirus infection
Arginine, among the amino acids, has demonstrated unique properties, including suppression of protein-protein interactions and virus inactivation. We investigated the effects of arginine on the infectivity of human herpesvirus 2 (HHV-2) and the potential application of arginine as a chemotherapeutic agent against genital herpes.
Keiko Ikeda+8 more
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Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene [PDF]
Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain,
Rollie J. Clem+6 more
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Herpesviruses are DNA viruses that infect humans and animals with the ability to induce latent and lytic infections in their hosts, causing critical health complications.
Miroslava Šudomová+1 more
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Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins [PDF]
ABSTRACT Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and ...
Aaron A. R. Tobian+9 more
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Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System
Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS).
Saima Ahmed+8 more
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Complete genome sequence and taxonomic position of anguillid herpesvirus 1 [PDF]
Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp
Abma-Henkens, M.H.C.+8 more
core +11 more sources
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip+8 more
core +2 more sources