Results 51 to 60 of about 575,515 (201)

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Herald Patch as the Only Evidence of Pityriasis Rosea: Clinical, Laboratory and Pathogenetic Features

Viruses
Pityriasis rosea (PR) is a self-limited exanthem associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and HHV-7. The disease typically begins with a single erythematous patch on the trunk (herald patch), followed by a ...
Francesco Drago, Astrid Herzum, Serena Varesano, Gaetano Serviddio, Francesco Broccolo, Giulia Ciccarese   +5 more
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

REGULATORY T-CELL ACTIVITY AS A MARKER OF POST–COVID-19 AND HERPETIC SECONDARY VASCULITIS IN YOUNG AND MATURE PATIENTS

Anti-Aging Eastern Europe
Background. Post-viral vasculitis represents a heterogeneous inflammatory condition in which persistent immune dysregulation following acute infection or viral reactivation contributes to vascular pathology.
Khrystyna Lishchuk-Yakymovych, Valentyna Chopyak, Omelian Synenkyi, Roman Pukalyak   +3 more
doaj   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Active herpesviruses are associated with intensive care unit (ICU) admission in patients pulmonary infection and alter the respiratory microbiome

Frontiers in Microbiology
BackgroundThe Herpesviridae family contains several human-related viruses, which are able to establish colonizing and latency in the human body, posing a significant threat to the prognosis of patients.
Zhiguang Liu, Chun-jian Qi, Yujia Shi, Tianyu Li, Yuan Fang, Qian Zhang, Qian Zhang   +6 more
doaj   +1 more source

Scoping Review of Sexual and Gender Minority Health Research in Ireland

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To map existing sexual and gender minority (SGM) health research in Ireland, identify gaps in literature and outline priorities for future research and healthcare. SGM is an umbrella term that includes people who identify as lesbian, gay, bisexual, transgender, queer or intersex and is sometimes abbreviated as LGBTQI+.
John P. Gilmore, Tonda L. Hughes, Sean Kearns, Laurie A. Drabble, Diarmuid Stokes, Siobhán D. Thomas, Chris Noone, Lauren Bochicchio   +7 more
wiley   +1 more source

Neurological involvement of human herpesvirus type 7 in the pediatric population: a rare presentation of a known disease

Revista Médica de Minas Gerais
Introduction: Human herpesvirus type 7 (HHV-7) is a common virus that typically causes self-limited infections in children, rarely affecting the central nervous system.
Lilian Martins Oliveira Diniz, Daniela Otoni Russo, Marina Melo Moreira, Bruna Campos Cardoso Vilela, Alessandra Noronha da Silva, Luisa Leal Barbosa Correia de Andrade, Lívia Barbosa da Silva, Ana Luisa Lodi Jimenez, Lorrane Luisa Lima Marques de Souza, Larissa Maria Armelin, Giselle Stephanie de Sousa Santos   +10 more
doaj   +1 more source

Multiple sclerosis and herpesvirus interaction

Arquivos de Neuro-Psiquiatria, 2013
Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components.
Guilherme Sciascia do Olival, Bruna Mendonca Lima, Laura M. Sumita, Vitor Serafim, Maria Cristina Fink, Luis Henrique Nali, Camila Malta Romano, Rodrigo Barbosa Thomaz, Vitor Breseghello Cavenaghi, Charles Peter Tilbery, Augusto Cesar Penalva-de-Oliveira   +10 more
doaj   +1 more source