Results 91 to 100 of about 575,450 (284)

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, EarlyView.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

In vitro and in vivo human herpesvirus 8 infection of placenta.

PLoS ONE, 2008
Herpesvirus infection of placenta may be harmful in pregnancy leading to disorders in fetal growth, premature delivery, miscarriage, or major congenital abnormalities.
Mariantonietta Di Stefano, Maria Luisa Calabrò, Iole Maria Di Gangi, Santina Cantatore, Massimo Barbierato, Elisa Bergamo, Anfumbom Jude Kfutwah, Margherita Neri, Luigi Chieco-Bianchi, Pantaleo Greco, Loreto Gesualdo, Ahidjo Ayouba, Elisabeth Menu, Josè Ramòn Fiore   +13 more
doaj   +1 more source

Incidence of HHV‐6 Reactivation in Drug Reaction With Eosinophilia and Systemic Symptoms and Correlation With RegiSCAR Score: A Retrospective Cohort Study

JEADV Clinical Practice, EarlyView.
Allison Holt, Baraa Hijaz, Joseph Ebriani, Bethany Brumbaugh, Mike Westmeijer, Madeline E. DeWane, Michael Stephens, John Trinidad, Kevin Sheng‐Kai Ma, Steven T. Chen   +9 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Human Herpesvirus 8 Induces Polyfunctional B Lymphocytes That Drive Kaposi’s Sarcoma

mBio, 2014
Kaposi’s sarcoma (KS) is an unusual neoplasia wherein the tumor consists primarily of endothelial cells infected with human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus) that are not fully transformed but are instead driven to excess ...
Emilee R. Knowlton, Giovanna Rappocciolo, Paolo Piazza, Lauren M. Lepone, Sagar V. Nadgir, Arlene Bullotta, Stella J. Berendam, Jun Li, Todd A. Reinhart, Frank J. Jenkins, Charles R. Rinaldo   +10 more
doaj   +1 more source

Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma [PDF]

, 1997
J Vieira, M.-L. Huang, David M. Koelle, Lawrence Corey   +3 more
openalex   +1 more source

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.

Proceedings of the National Academy of Sciences of the United States of America, 1997
The Bcl-2 protein family is characterized by the ability to modulate cell death, and members of this family share two highly conserved domains called Bcl-2 homology 1 (BH1) and 2 (BH2) which have been shown to be critical for the death-repressor activity
E. Cheng, J. Nicholas, D. Bellows, G. Hayward, Hong Guano Guo, Marvin S. Reitz, J. Hardwick   +6 more
semanticscholar   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Human Herpesvirus 8 Is Present in the Lymphoid System of Healthy Persons and Can Reactivate in the Course of AIDS [PDF]

, 1996
Beatrice Bigoni, R. DoIcetti, Laura De Lellis, Antonino Carbone, M Boiocchi, Enzo Cassai, Dario Di Luca   +6 more
openalex   +1 more source

Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial.

Journal of Infectious Diseases, 2008
BACKGROUND Human herpesvirus-8 (HHV-8) replication is critical in the induction and maintenance of Kaposi sarcoma, primary effusion lymphoma, and some cases of Castleman disease.
C. Casper, Elizabeth M. Krantz, L. Corey, S. Kuntz, Jie Wang, S. Selke, S. Hamilton, Meei-Li W Huang, A. Wald   +8 more
semanticscholar   +1 more source