Results 91 to 100 of about 9,697,114 (241)

The ‘Human Rights Component’ of Foreign Policy

, 2022
Framed into the broader conceptual debate that addresses the controversial role of human rights in the foreign policies of states, this book aims to critically investigate whether, how and to what extent human rights matter in the definition of Italy’s ...
de Perini, Pietro
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Diatom detection in drowning investigations and environmental analysis – development of a highly sensitive species-specific PCR assay [PDF]

, 2018
Poster presented at Human Identification Solutions (HIDS) Rome, 3rd-4th May, 2018, Rome ...
Schmerer, Wera Margarete, Franks, Thomas
core   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Enantiospecific Synthesis, Chiral Separation, and Biological Activity of Four Indazole-3-Carboxamide-Type Synthetic Cannabinoid Receptor Agonists and Their Detection in Seized Drug Samples

Frontiers in Chemistry, 2019
Synthetic cannabinoid receptor agonists (SCRAs) have been the largest group of illicit psychoactive substances reported to international monitoring and early warning systems for many years. Carboxamide-type SCRAs are amongst the most prevalent and potent.
Lysbeth H. Antonides, Lysbeth H. Antonides, Annelies Cannaert, Annelies Cannaert, Caitlyn Norman, Loelia Vives, Loelia Vives, Aidan Harrison, Andrew Costello, Andrew Costello, Niamh Nic Daeid, Niamh Nic Daeid, Christophe P. Stove, Oliver B. Sutcliffe, Oliver B. Sutcliffe, Craig McKenzie   +15 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Soft biometrics; human identification using comparative descriptions

, 2014
Soft biometrics are a new form of biometric identification which use physical or behavioral traits that can be naturally described by humans. Unlike other biometric approaches, this allows identification based solely on verbal descriptions, bridging the ...
Reid, Daniel, Nixon, Mark S., Stevenage, Sarah V.   +2 more
core   +1 more source

Environmental DNA analysis – non-invasive detection of endangered species in aquatic and terrestrial environments [PDF]

, 2017
Poster presented at Human Identification Solutions (HIDS) 2017, 16th-17th May, 2017, Vienna ...
Schmerer, Wera M, Halford, Carl M, Hill, David, Clack, Deborah E, Moreton-Jones, Karl J   +4 more
core   +2 more sources