Results 41 to 50 of about 377,024 (261)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients

Brazilian Journal of Infectious Diseases, 2014
Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China.
Haohui Zhu, Jianjun Yuan, Yisa Wang, Fan Gao, Xiao Wang, Changhua Wei, Jiyun Chen, Xiaohui Fan, Mei Zhang   +8 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Determinants of HIV infection among infants born to HIV positive women receiving option B + prevention of mother to child transmission of HIV in Tigray, north Ethiopia: a case control study

AIDS Research and Therapy
Background The option B+ prevention of mother to child transmission of human immunodeficiency virus is the lifelong provision of antiretroviral therapy for all human immunodeficiency virus positive pregnant and breastfeeding women regardless of immune ...
Haftay Gebremedhin, Fre Gebremeskel, Gebremedhin Gebreegziabiher, Abadi Hailay Atsbaha, Gebretekle Gebremichael Hailesilase   +4 more
doaj   +1 more source

Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals

Brazilian Journal of Infectious Diseases, 2016
Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new ...
Cezar Arthur Tavares Pinheiro, Luciano Dias de Mattos Souza, Janaína Vieira dos Santos Motta, Evelin Franco Kelbert, Clarissa de Souza Ribeiro Martins, Marília Silva de Souza, Karen Amaral Tavares Pinheiro, Fábio Monteiro da Cunha Coelho, Ricardo Tavares Pinheiro   +8 more
doaj   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Trends and spatial patterns of human immunodeficiency virus prevalence among men and women aged 15–49 in Sierra Leone: evidence from the 2008, 2013 and 2019 Demographic and Health Surveys

BMJ Global Health
Background Human immunodeficiency virus prevalence remains a major public health concern in Sierra Leone. This study examines the trends and spatial patterns of human immunodeficiency virus prevalence among men and women in Sierra Leone using data from ...
Wei Ma, Augustus Osborne, Lovel Fornah, Mulugeta Shegaze Shimbre   +3 more
doaj   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Routine immunization uptake and timeliness in young children exposed to multidrug-resistant tuberculosis: A secondary analysis of the Tuberculosis Child Multidrug-Resistant Preventive Therapy multi-site randomised controlled trial

BMC Global and Public Health
Background The Expanded Programme on Immunization (EPI) reduces vaccine preventable disease-related childhood morbidity and mortality. Vaccine coverage and timeliness are crucial to maximise protection in children  5 days before, within 28 days of, and > 
Faeezah Patel, Susan Purchase, Mrinmayee Dhar, Elizea Horne, Janet Grab, Hamisha Soma-Kasiram, Nadia Sabet, Neil Martinson, Suzanne Staples, Joanna Brigden, Thomas Wilkinson, Hendrik Simon Schaaf, James Seddon, Lee Fairlie, Anneke Hesseling, Trinh Duong   +15 more
doaj   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source