Results 121 to 130 of about 8,175,458 (300)

Valuing Human Impact of Natural Disasters: A Review of Methods. [PDF]

Int J Environ Res Public Health, 2022
Kharb A, Bhandari S, Moitinho de Almeida M, Castro Delgado R, Arcos González P, Tubeuf S.   +5 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Diversity, dynamics and biogeography of Chilean benthic nearshore ecosystems: an overview and guidelines for conservation Diversidad, dinámica y biogeografía del ecosistema costero bentónico de Chile: revisión y bases para conservación marina

Revista Chilena de Historia Natural, 2000
Despite Chile has been one of the pioneering countries in studies of human impact on marine communities, and despite the enormous economic and social significance that the marine environment has for the country, the development of marine conservation ...
MIRIAM FERNANDEZ, EDUARDO JARAMILLO, PABLO A MARQUET, CARLOS A MORENO, SERGIO A NAVARRETE, F. PATRICIO OJEDA, CLAUDIO R VALDOVINOS, JULIO A VASQUEZ   +7 more
doaj  

Can the Wolf (Canis lupus) Thrive in Highly Anthropised Lowlands? First Habitat Suitability Analysis of the Po Plain, Italy

Animals
Coexisting with large carnivores in human-dominated European landscapes is a highly relevant and current challenge. Over the last two centuries, the wolf (Canis lupus) population in Europe has experienced a significant decline, primarily due to direct ...
Luca Fardone, Martina Forlani, Luca Canova, Matteo De Luca, Alberto Meriggi   +4 more
doaj   +1 more source

Microbial diversity and proxy species for human impact in Italian karst caves. [PDF]

Sci Rep, 2023
Biagioli F, Coleine C, Piano E, Nicolosi G, Poli A, Prigione V, Zanellati A, Varese C, Isaia M, Selbmann L.   +9 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Human impacts [PDF]

Nature Climate Change, 2015
openaire   +2 more sources

Human resources impact assessment.

Bulletin of the World Health Organization, 2003
Has been published before in: Bull.
Van Lerberghe, W., Adams, O., Ferrinho, P.   +2 more
openaire   +3 more sources

Early human impact on lake cyanobacteria revealed by a Holocene record of sedimentary ancient DNA. [PDF]

Commun Biol, 2023
Nwosu EC, Brauer A, Monchamp ME, Pinkerneil S, Bartholomäus A, Theuerkauf M, Schmidt JP, Stoof-Leichsenring KR, Wietelmann T, Kaiser J, Wagner D, Liebner S.   +11 more
europepmc   +1 more source