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Climate Challenge for 11-14 years: Explore the human impact of climate change
, 2015 Our Climate Challenge resources for 11–14 years old focus on the human impact of climate change: how communities around the world are being affected by climate change and how people are responding and adapting to these challenges.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Human Rights Impact Assessment in the Context of Biofuels: Addressing the Human Right to Food and the Human Right to Water [PDF]
, 2010 The original mandate of the UN Special Representative on Business and Human Rights said that he should „develop materials and methodologies for undertaking human rights impact assessments.‟ Since then, tools for human rights impact assessment (HRIA) have
Haugen, Hans Morten
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Community Essay: Sustainability science – and what’s needed beyond science
Sustainability: Science, Practice, & Policy, 2005 Educating broadly about the science and technologies of sustainability is essential, because it convinces us that a successfully sustainable future is being undermined.
Paul H. Reitan
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
This discussion paper focuses on the commitments that Dutch, German and UK supermarkets made as part of the Behind the Barcodes campaign to conduct human rights impact assessments (HRIAs). To understand whether supermarkets are meaningfully
Achterberg, Eline
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
AI-Generated News Content: The Impact of AI Writer Identity and Perceived AI Human-Likeness
As AI-generated news expands with advancing media technology, understanding its impact on consumer engagement becomes increasingly important. This study investigates how readers’ awareness of an article’s AI or human authorship affects their engagement ...
Baek, TH, Jhang, J, Lee, DC
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