Results 121 to 130 of about 8,254,808 (300)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Knowledge management: Exploring the relationship between human capital and organisation structure capital [PDF]

, 2010
Human capital and its impact on the organisation structure capital are of paramount importance in the modern business organisations. This research in progress, which investigates and analyses the role that human capital plays in the determination of the ...
Al-Halak, A, Al-Karaghouli, W, Ghoneim, A, Koufopoulos, D   +3 more
core  

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

, 2018
Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action
Iida, Midori, Takemoto, Kazuhiro
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Valuing Human Impact of Natural Disasters: A Review of Methods. [PDF]

Int J Environ Res Public Health, 2022
Kharb A, Bhandari S, Moitinho de Almeida M, Castro Delgado R, Arcos González P, Tubeuf S.   +5 more
europepmc   +1 more source

Designing ambient intelligent scenarios to promote discussion of human values [PDF]

, 2005
Ambient technology evokes a near future in which humans will be surrounded by ‘always-on’, unobtrusive, interconnected intelligent objects. Always connected raises concern over human values.
Briggs, Pamela, Little, Linda
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Human impacts [PDF]

Nature Climate Change, 2015
openaire   +2 more sources

Microbial diversity and proxy species for human impact in Italian karst caves. [PDF]

Sci Rep, 2023
Biagioli F, Coleine C, Piano E, Nicolosi G, Poli A, Prigione V, Zanellati A, Varese C, Isaia M, Selbmann L.   +9 more
europepmc   +1 more source

Human resources impact assessment.

Bulletin of the World Health Organization, 2003
Has been published before in: Bull.
Van Lerberghe, W., Adams, O., Ferrinho, P.   +2 more
openaire   +3 more sources