Results 211 to 220 of about 2,869,907 (257)
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
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2021
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush +3 more
openaire +1 more source
Science
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
Behind the myriad upheavals U.S. science has faced during the first 100 days of President Donald Trump’s administration, countless researchers are fighting for their careers and aspirations.
Sara, Reardon +3 more
openaire +2 more sources
1992
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
Abstract Environmental change spans all of human time. Even so-called primitive peoples have left their mark on the earth. Fire, the oldest of anthropogenic landscape modifiers, has long been implicated in the origins and maintenance of tropical savannahs and mid-latitude grasslands, and biggame hunters of the Stone Age may have caused ...
S Robert Aiken, Colin H Leigh
openaire +1 more source
Telepresence Robots and Their Impact on Human-Human Interaction
2020In an increasingly globalized world remote communication becomes ever more crucial. Hence, telepresence robots gain importance as they simplify attending important but distant events. However, research regarding human affinity towards a person by interacting directly or through a telepresence robot with another individual has not been undertaken ...
Lisa Keller +3 more
openaire +2 more sources
1985
The fundamental role of climate for the fate of mankind is increasingly being recognized at both the international and national levels (World Meteorological Organization, 1980, pp. 7–10, 28–37; World Meteorological Organization-ICSU, 1975, pp. 1–3; United Nations Environment Programme, 1979, pp. 1–16; National Climate Program Office NOAA, 1980, pp. 1–4,
openaire +1 more source
The fundamental role of climate for the fate of mankind is increasingly being recognized at both the international and national levels (World Meteorological Organization, 1980, pp. 7–10, 28–37; World Meteorological Organization-ICSU, 1975, pp. 1–3; United Nations Environment Programme, 1979, pp. 1–16; National Climate Program Office NOAA, 1980, pp. 1–4,
openaire +1 more source