Results 131 to 140 of about 2,769,848 (257)

Complex Variation in Afrotropical Mammal Communities With Human Impact. [PDF]

Ecol Evol
Tuyisingize D, Kulik L, Assou D, Zausa D, Kamga S, Mundi O, Heinicke S, Kone I, Mucyo SJP, Sop T, Boesch C, Stephens C, Agbor A, Angedakin S, Bailey E, Bessone M, Coupland C, Head J, Deschner T, Dieguez P, Egbe VE, Granjon AC, Hicks TC, Jones S, Kalan AK, Langergraber KE, Lapuente J, Lee KC, Lynn LK, Maldonado N, McCarthy MS, Meier A, Ormsby LJ, Piel AK, Sciaky L, Sommer V, Stewart FA, Wessling EG, Widness J, Wittig RM, Strohbach P, Arandjelovic M, van der Hoek Y, Kühl HS.   +43 more
europepmc   +1 more source

The past and future human impact on mammalian diversity. [PDF]

Sci Adv, 2020
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D.   +4 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Rapid development of an online tracker to communicate the human impact of abruptly halting PEPFAR support. [PDF]

J Int AIDS Soc
Nichols BE, Geng EH, Moakley E, Phillips AN, Imai-Eaton JW, Stover J, Mudimu E, Grimsrud A.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

8,000 years of wild and domestic animal body size data reveal long-term synchrony and recent divergence due to intensified human impact. [PDF]

Proc Natl Acad Sci U S A
Mureau C, d'Oliveira L, Peyron O, Blaise E, Renaud A, Balcarcel A, Jeanjean M, Bonhomme V, Bouby L, Ros J, Evin A.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

MultiAgency, prospective, exploratory, non-intervention, cohort Study on Human Impact Exposure oNboard high-speed boats (MASHIEN): protocol. [PDF]

BMJ Open
Ullman J, Myers SD, Bretschneider KT, Kelly KR, Daniel Y, Hurpin V, Kaehler J, Kåsin JI, Hveding K, Mansfield N, Masouros SD, Perl D, Wijnands N, Vallee I, Stevens V, Fraser JJ, Rolfson O, Robinson Y.   +17 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source