Results 141 to 150 of about 2,769,848 (257)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Capturing the human impact of living with multiple long-term conditions in routine electronic health records - lost in translation? [PDF]

J Multimorb Comorb
Fraser SDS, Holland E, Laidlaw L, Francis NA, Macdonald S, Mair FS, Alwan NA, Boniface M, Hoyle RB, Fair N, Dylag JJ, Shiranirad M, Chiovoloni R, Stannard S, Poole R, Akbari A, Ashworth M, Dregan A.   +17 more
europepmc   +1 more source

Fox dietary ecology as a tracer of human impact on Pleistocene ecosystems. [PDF]

PLoS One, 2020
Baumann C, Bocherens H, Drucker DG, Conard NJ.   +3 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Integrating seasonal dynamics and human impact on microbial biomass carbon across deep soil profiles in tropical Sal forest of Achanakmar-Amarkantak Biosphere Reserve, India. [PDF]

Sci Rep
Singh S, Dixit B, Singh A, Prajapati L, Chandrakar S, Tamrakar A.   +5 more
europepmc   +1 more source

The human impact on North American erosion, sediment transfer, and storage in a geologic context. [PDF]

Nat Commun, 2020
Kemp DB, Sadler PM, Vanacker V.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Montane rainforest dynamics under changes in climate and human impact during the past millennia in northern Madagascar. [PDF]

R Soc Open Sci
Montade V, Bremond L, Teixeira H, Kasper T, Daut G, Rouland S, Rasoamanana E, Ramavovolona P, Favier C, Arnaud F, Radespiel U, Behling H.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Human Impact on the Twenty-Four-Hour Patterns of Steller Sea Lions' Use of a Haulout in Hokkaido, Japan. [PDF]

Animals (Basel)
Chayahara Y, Nakanowataru Y, Abe S, Kurosawa R, Suma S, Murasato N, Oyamada R, Ebashi N, Tsunokawa M, Sakurama M, Kooriyama T.   +10 more
europepmc   +1 more source