Results 61 to 70 of about 578,251 (255)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Human Ecology 33:1, April 2005, Impact of Human ecology Research

, 2005
Impact of Human Ecology Research, and 2003-04 Annual Report of the College of Human ...
College of Human Ecology
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Workers Behind the Citrus Fruits: A focused Human Rights Impact Assessment of Coop Sweden’s Moroccan citrus fruit supply chains

, 2022
This paper reports on a focused human rights impact assessment (HRIA) of Coop Sweden’s Moroccan citrus supply chains. The HRIA aimed to assess the actual and potential human rights impacts at the production stage of the value chain in ...
Alestig, Mira, Banerji, Sabita
core   +1 more source

Trust and overreliance on ChatGPT and its implications on critical thinking: an exploration in health policy

Discover Public Health
International organizations have provided guidelines for the use of AI, encouraging its responsible development and promoting human-centered, trust-based use.
Carlos Alberto Rosas-Jiménez, Cynthia Lokker, Bonny Ibhawoh, Lisa Schwartz   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Human impact on western lowland gorilla behaviour [PDF]

, 2010
First paragraph: Western lowland gorilla tourism exists on a considerably smaller scale than that of the high profile mountain gorillas. Yet the successful habituation of several western lowland gorilla groups, combined with demand from international ...
Lee, Phyllis C, Klailova, Michelle, Hodgkinson, Chloe   +2 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The future of human rights impact assessments of trade agreements

, 2009
The Future of Human Rights Impact Assessments of Trade Agreements develops a methodology for human rights impact assessments of trade agreements and considers whether there is any value in using the methodology on a sustained basis to ensure that the ...
Studie- en Informatiecentrum Mensenrecht, Human Rights in a World of Conflict and Diversity. Conceptualisation and Implementation of Human Rights (t/m 2009), Walker, S.M.   +2 more
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