Results 101 to 110 of about 578,251 (255)
Biological Activity of Mountain Soils of the Western Caucasus after Deforestation
Лесной журналA study of a set of indicators characterizing the ecological state of forest soils in the mountains of the North-Western Caucasus under broad-leaved and mixed forests has been conducted.
Aslan K. Shkhapatsev +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
UNC Wilmington College of Health and Human Services 2023 impact report
, 2023 UNCW College of Health and Human Services' priorities, mission and values, strategic plan, degree progams, and ...
University of North Carolina, Wilmington. College of Health and Human Services
core
Knowledge and Management of Aquatic Ecosystems, 2018 We studied the variability of physico-chemical parameters in water, and heavy metal contents in water and sediment over time and along the Carpathian Biała Tarnowska River (southern Poland) and related them to catchment geology, human impact and the ...
Szarek-Gwiazda Ewa +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Multi-Disciplinary Impact: Faculty Shine in Cross-Campus Collaboration
, 2017 Improving Lives by Exploring and Shaping Human Connections to Natural, Social and Built Environments.College of Human ...
College of Human Ecology
core
UNC Wilmington College of Health and Human Services 2022 impact report
, 2022 UNCW College of Health and Human Services' priorities, mission and values, strategic plan, degree progams, and ...
University of North Carolina, Wilmington. College of Health and Human Services
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source