Results 131 to 140 of about 18,809,909 (341)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Support for Integrated Ecosystem Assessments of NOAA’s National Estuarine Research Reserves System (NERRS), Volume I: The Impacts of Coastal Development on the Ecology and Human Well-being of Tidal Creek Ecosystems of the US Southeast [PDF]

, 2008
A study was conducted, in association with the Sapelo Island and North Carolina National Estuarine Research Reserves (NERRs), to evaluate the impacts of coastal development on sentinel habitats (e.g., tidal creek ecosystems), including potential impacts ...
Bergquist, D., Blair, A., Chapman, R., DiDonato, G., Jones, S., Riekerk, G., Sanger, D., Stewart, J., Vandiver, L., Washburn, T., Whitall, D., White, D., White, S., Wirth, E.   +13 more
core  

Ancient harbour infrastructure in the Levant: tracking the birth and rise of new forms of anthropogenic pressure

, 2014
Beirut, Sidon and Tyre were major centres of maritime trade from the Bronze Age onwards. This economic prosperity generated increased pressures on the local environment, through urbanization and harbour development.
Carayon, N., Kaniewski, D., Marriner, N., Morhange, C.   +3 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Human Impact

The American Biology Teacher, 2018
Earth in Human Hands: Shaping Our Planet's Future . By David Grinspoon. 2016. Grand Central Publishing. (ISBN 9781455589128). 522 pages. Hardcover. $28.00. Dr. Grinspoon's massive review of Earth's past, present, and future begins with a nod to the Anthropocene and the idea that humans, with regard to the state of the planet, are “at the controls ...
openaire   +2 more sources

Dragging the chain: anchor scour impacts from high-tonnage commercial vessels on a soft bottom macrobenthic assemblage

Frontiers in Conservation Science
International shipping is the backbone of the global economy with ~80% of the world’s trade (by volume) transported by ship. The potential environmental impacts of this multi-billion-dollar industry have received considerable attention, particularly ...
Andrew R. Davis, Allison Broad, Chantel Steele, Caitlin Woods, Rachel Przeslawki, Rachel Przeslawki, W. A. (Tony) Nicholas, W. A. (Tony) Nicholas, William Maher, Frank Krikowa, Bradley Morris, Timothy C. Ingleton, Timothy C. Ingleton, Sarah O’Hea Miller, Matthew J. Rees   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

INSECT POPULATION DYNAMICS, PESTICIDE USE AND FARMWORKER HEALTH REVISITED: PESTICIDE CHOICE AND RISK MITIGATION [PDF]

Several policies to reduce worker exposure, dietary and environmental risks are examined in the context of pesticide choice driven by insect population dynamics.
Wyatt, T.J.
core   +1 more source