Results 191 to 200 of about 18,809,909 (341)

Unpredicted ecosystem response to compound human impacts in a European river. [PDF]

Sci Rep
Köhler J, Varga E, Spahr S, Gessner J, Stelzer K, Brandt G, Mahecha MD, Kraemer G, Pusch M, Wolter C, Monaghan MT, Stöck M, Goldhammer T.   +12 more
europepmc   +2 more sources

Changes of lake organic carbon sinks from closed basins since the Last Glacial Maximum and quantitative evaluation of human impacts. [PDF]

Carbon Balance Manag, 2021
Li Y, Zhang X, Xu L, Zhang Y, Ye W, Li Y.   +5 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Late Pleistocene faunal community patterns disrupted by Holocene human impacts. [PDF]

Biol Lett
Brook BW, Lyons SK, Carter BE, Gearty W, Todorov OS, Aandahl Z, Alroy J.   +6 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Shifting seas: understanding deep-time human impacts on marine ecosystems. [PDF]

Philos Trans R Soc Lond B Biol Sci
Holman LE, Bohmann K, Craig OE, Orton D, Pedersen MW, Tange Olsen M, Thurstan RH, Scourse J.   +7 more
europepmc   +1 more source

Multinational Corporations, Technology Spillovers and Human Rights's Impacts on Developing Countries [PDF]

This paper stems from the recognition that, in the current globalized world, the achievement of economic development goals is not necessarily accompanied by improved social conditions, or respect of people?s human rights more generally.
Elisa Giuliani
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Deconstructing the geography of human impacts on species' natural distribution. [PDF]

Nat Commun
Waldock C, Wegscheider B, Josi D, Calegari BB, Brodersen J, Jardim de Queiroz L, Seehausen O.   +6 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source