Results 211 to 220 of about 18,809,909 (341)

Editorial: The importance of understanding benthic ecosystem functioning

Frontiers in Marine Science
Irini Tsikopoulou, Federica Nasi, Julie Bremner   +2 more
doaj   +1 more source

Environmental Gradients Linked to Human Impacts, Not Species Richness, Drive Regional Variation in Community Stability in Coral Reef Fishes. [PDF]

Ecol Lett
Tsai CH, Connolly SR.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cumulative human impacts on global marine fauna highlight risk to biological and functional diversity. [PDF]

PLoS One
O'Hara CC, Frazier M, Valle M, Butt N, Kaschner K, Klein C, Halpern BS.   +6 more
europepmc   +1 more source

Global priorities for conservation of reptilian phylogenetic diversity in the face of human impacts. [PDF]

Nat Commun, 2020
Gumbs R, Gray CL, Böhm M, Hoffmann M, Grenyer R, Jetz W, Meiri S, Roll U, Owen NR, Rosindell J.   +9 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Early to Mid-Holocene land use transitions in South Asia: A new archaeological synthesis of potential human impacts. [PDF]

PLoS One
Bates J, Morrison KD, Madella M, Hill AC, Whitehouse NJ, Abro T, Ajithprasad P, Anupama K, Casile A, Chandio A, Chatterjee S, Gangopadhyay K, Hammer E, Haricharan S, Hazarika M, Korisettar R, Kumar A, Lancelotti C, Pappu S, Parque O, Petrie CA, Premathilake R, Selvakumar V, Sen S, Spate M, Trivedi M, Veesar GM, Vinayak V.   +27 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Human Impacts on Great Lakes Walleye Sander vitreus Structure, Diversity and Local Adaptation. [PDF]

Mol Ecol
Euclide PT, Kuhl H, Wilson CC, Scribner KT, Miller LM, Stott W, Larson WA.   +6 more
europepmc   +1 more source