Results 271 to 280 of about 18,809,909 (341)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Site-Dependent Dynamic Life Cycle Assessment of Human Health Impacts from Industrial Air Pollutants: Inhalation Exposure to NO_x, SO₂, and PM_2.5 in PVC Window Manufacturing. [PDF]

Toxics
Megange P, Feiz AA, Ngae P, Le TP, Rousseaux P.   +4 more
europepmc   +1 more source

The failure to protect the rights and needs of children in Gaza. [PDF]

Front Public Health
Bessell S, O'Sullivan C.
europepmc   +1 more source

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Human impacts

Ecology of Coastal Marine Sediments, 2021
Coastal soft sediments are closely linked to human activity both on the land and at sea and consequently they are subjected to a wide array of human impacts. Looking for some general patterns in the consequences of impacts, this chapter identifies a range of different ecological changes as a result of direct impacts and then moves to address indirect ...
Simon F. Thrush, Judi E. Hewitt, Conrad A. Pilditch, Alf Norkko   +3 more
openaire   +2 more sources

Human impacts outpace natural processes in the Amazon

Science, 2023
Amazonian environments are being degraded by modern industrial and agricultural activities at a pace far above anything previously known, imperiling its vast biodiversity reserves and globally important ecosystem services.
J. Albert, A. Carnaval, S. Flantua, L. Lohmann, C. C. Ribas, D. Riff, J. D. Carrillo, Ying Fan, J. Figueiredo, J. Guayasamin, C. Hoorn, G. H. D. de Melo, Nathália Nascimento, C. Quesada, Carmen Ulloa Ulloa, P. Val, J. Arieira, A. Encalada, C. Nobre   +18 more
semanticscholar   +1 more source

At-risk marine biodiversity faces extensive, expanding, and intensifying human impacts

Science, 2021
An ever-growing human footprint Human activities are increasingly affecting the marine environment but understanding how much and in what ways is an extreme challenge given the vastness of this system. O'Hara et al.
C. O’Hara, Melanie Frazier, B. Halpern
semanticscholar   +1 more source

Human Impacts

Science and Children
Elizabeth Barrett-Zahn
semanticscholar   +3 more sources

Human impacts

Ecology of Coastal Marine Sediments, 2007
openaire   +2 more sources

Human Impacts

Human Impact on the Environment: Ancient Roots, Current Challenges, 2019
openaire   +2 more sources