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First human infection with Onchocerca takaokai (Spirurida: Onchocercidae) presenting as creeping eruption in Japan [PDF]

Parasite
Zoonotic onchocerciasis is a rare human infection caused by Onchocerca species that normally parasitize non-human mammals. In Japan, all previously reported human cases have been attributed to Onchocerca japonica and have presented as localized, non ...
Ikenaga Eri, Nagayasu Eiji, Hasegawa Hideo, Murota Hiroyuki, Kuwatsuka Yutaka   +4 more
doaj   +2 more sources

Development and characterization of a panel of anti-idiotype antibodies to 1C10 that cross-neutralize HIV-1 subtype B viruses

Frontiers in Virology, 2022
The V3 loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is one of the conserved immunogenic regions targeted by neutralizing antibodies (nAb).
Yu Kaku, Kaho Matsumoto, Takeo Kuwata, Hasan Md Zahid, Shashwata Biswas, Miroslaw K. Gorny, Shuzo Matsushita   +6 more
doaj   +1 more source

Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians

AIDS Research and Therapy, 2021
Background For over a decade, antiretroviral therapy (ART) in resource-limited countries was only recommended for patients with advanced HIV disease.
Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George P. Judicate, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno   +8 more
doaj   +1 more source

Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG

Retrovirology, 2021
Background Recent data suggest the importance of non-neutralizing antibodies (nnAbs) in the development of vaccines against HIV-1 because two types of nnAbs that recognize the coreceptor binding site (CoRBS) and the C1C2 region mediate antibody-dependent
Hasan Md Zahid, Takeo Kuwata, Shokichi Takahama, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Hirokazu Tamamura, Shuzo Matsushita   +7 more
doaj   +1 more source

Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate

Frontiers in Microbiology, 2021
HIV human immunodeficiency virus type I (HIV-1) entry inhibitor potency is dependent on viral co-receptor tropisms and thereby tropism determination is clinically important.
George P. Judicate, Godfrey Barabona, Doreen Kamori, Macdonald Mahiti, Toong Seng Tan, Seiya Ozono, Amina Shaban Mgunya, Takeo Kuwata, Shuzo Matsushita, Bruno Sunguya, Bruno Sunguya, Eligius Lyamuya, Eligius Lyamuya, Kenzo Tokunaga, Kenzo Tokunaga, Takamasa Ueno, Takamasa Ueno   +16 more
doaj   +1 more source

Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine

Nature Communications, 2022
mRNA vaccines have been shown to prevent SARS-CoV-2 infection and reduce hospitalization and mortality rates. Here, the authors show evidence of long-term memory CD8 + T cells in individuals who received the BNT162b2 SARS-CoV-2 mRNA vaccine.
Nozomi Kuse, Yu Zhang, Takayuki Chikata, Hung The Nguyen, Shinichi Oka, Hiroyuki Gatanaga, Masafumi Takiguchi   +6 more
doaj   +1 more source

Mild Positive Pressure Improves the Efficacy of Benzalkonium Chloride against Staphylococcus aureus Biofilm

Bioengineering, 2022
Current protocols using liquid disinfectants to disinfect heat-sensitive hospital items frequently fail, as evidenced by the continued isolation of bacteria following decontamination. The contamination is, in part, due to biofilm formation.
Shamaila Tahir, Sarah Emanuel, David W. Inglis, Karen Vickery, Anand K. Deva, Honghua Hu   +5 more
doaj   +1 more source

M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

Retrovirology, 2020
Background HIV-1 promotes the formation of tunneling nanotubes (TNTs) that connect distant cells, aiding cell-to-cell viral transmission between macrophages.
Sameh Lotfi, Hesham Nasser, Osamu Noyori, Masateru Hiyoshi, Hiroaki Takeuchi, Yoshio Koyanagi, Shinya Suzu   +6 more
doaj   +1 more source

Inflammatory and interferon gene expression signatures in patients with mitochondrial disease

Journal of Translational Medicine, 2023
Background People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection.
Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West, Peter J. McGuire   +12 more
doaj   +1 more source

Human Thelaziosis Caused by Thelazia callipaeda Eyeworm, Hungary

Emerging Infectious Diseases, 2022
Ocular infections with Thelazia callipaeda eyeworms in Europe have become more common. We report a case in Hungary caused by T. callipaeda eyeworms in a 45-year-old woman who had no travel history abroad.
Hajnalka Juhász, Géza Thury, Mária Szécsényi, Edit Tóth-Molnár, Katalin Burián, Zoltán Deim, Gabriella Terhes   +6 more
doaj   +1 more source