Results 71 to 80 of about 535,803 (298)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genomic Signatures of Human versus Avian Influenza A Viruses

Emerging Infectious Diseases, 2006
Position-specific entropy profiles created from scanning 306 human and 95 avian influenza A viral genomes showed that 228 of 4,591 amino acid residues yielded significant differences between these 2 viruses.
Guang-Wu Chen, Shih-Cheng Chang, Chee-Keng Mok, Yu-Luan Lo, Yu-Nong Kung, Ji-Hung Huang, Yun-Han Shih, Ji-Yi Wang, Chiayn Chiang, Chi-Jene Chen, Shin-Ru Shih   +10 more
doaj   +1 more source

Incidence and viral aetiologies of acute respiratory illnesses (ARIs) in the United States: a population-based study. [PDF]

, 2016
We conducted prospective, community-wide surveillance for acute respiratory illnesses (ARIs) in Rochester, NY and Marshfield, WI during a 3-month period in winter 2011.
Albertin, C, Blumkin, A, Donahue, JG, Gallivan, S, Lofthus, GK, Schnabel, KC, Shay, DK, Szilagyi, PG, Thompson, MG, Treanor, JJ   +9 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Impact of the COVID-19 pandemic on influenza vaccination coverage in Latin America: Southern Cone, Argentina, Chile, and Uruguay

Revista Panamericana de Salud Pública
Objective. Analyze the impact of the COVID-19 pandemic on influenza vaccination coverage in some countries in the Americas. Methods. This descriptive ecological study included Argentina, Chile, and Uruguay and analyzed information on influenza ...
Pablo Bonvehi, Ruby Trejo Varon, Carlos Espinal, Helena Brenes Chacon, Francisco Becerra-Posada   +4 more
doaj   +1 more source

Immunity to Influenza Infection in Humans [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
This review discusses the human immune responses to influenza infection with some insights from studies using animal models, such as experimental infection of mice. Recent technological advances in the study of human immune responses have greatly added to our knowledge of the infection and immune responses, and therefore much of the focus is on recent ...
Topham, David J., DeDiego, Marta L., Nogales, Aitor, Sangster, Mark Y., Sant, Andrea   +4 more
openaire   +3 more sources

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses [PDF]

, 2018
Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to ...
AC Banyard, AGD Bean, B Hu, CR Gaush, D Bernasconi, D Dlugolenski, DS Poole, EA Govorkova, GS Freidl, I Eckerle, I Ramos, Isabella Eckerle, J Stevens, J Xie, K Shuai, Kin-Chow Chang, M Delgado-Ortega, M Hoffman, M Juozapaitis, O Planz, R Pinto, RK Nelli, RK Nelli, S Matikainen, S Panzer, S Tong, SH Seo, SJ Gamblin, SV Kuchipudi, Tessa Slater, V Sandekian, W Weis, Y Wu   +32 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Detecting Human-to-Human Transmission of Avian Influenza A (H5N1)

Emerging Infectious Diseases, 2007
Highly pathogenic avian influenza A (HPAI) subtype H5N1 has caused family case clusters, mostly in Southeast Asia, that could be due to human-to-human transmission.
Yang Yang, M. Elizabeth Halloran, Jonathan D. Sugimoto, Ira M. Longini   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source