Results 71 to 80 of about 7,903,746 (290)

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies

Scientific Reports, 2022
During the current coronavirus disease 2019 (COVID-19) pandemic, symptoms of depression are commonly documented among both symptomatic and asymptomatic quarantined COVID-19 patients.
Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair, Mokhtar R. Gomaa, Ahmed N. El-Taweel, Noura M. Abo Shama, Mohamed GabAllah, Dina B. Mahmoud, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil, Ahmed Mostafa   +12 more
doaj   +1 more source

Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E

Microorganisms, 2023
Repurposing vitamins as antiviral supporting agents is a rapid approach used to control emerging viral infections. Although there is considerable evidence supporting the use of vitamin supplementation in viral infections, including severe acute ...
Yassmin Moatasim, Omnia Kutkat, Ahmed M. Osman, Mokhtar R. Gomaa, Faten Okda, Mohamed El Sayes, Mina Nabil Kamel, Mohamed Gaballah, Ahmed Mostafa, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil   +12 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2014
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, which have been suggested to evolve in pigs from viral genes
Metreveli, Giorgi
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective. [PDF]

, 2011
Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of ...
Kerac, Marko, Zanuzdana, A, Augustine, G, Kim, Sophie, Mukaigawara, M, Denness, H, Harris, Rebecca C., Parish, V, Stevenson, Charlotte, Wigglesworth, N, Haroon, M, Paul Fisher, Javier Peñalver, Beck, Charles R., Gemma Morgan, Charlotte Stevenson, Butt, Mobasher, Puleston, Richard, Vivienne Parish, Haroon, S, Rebecca C Harris, Hiroshi Horiuchi, Ahyow, L, Bruce C McKenzie, Jose Figureroa, Joanne Enstone, Marko Kerac, Puleston, R, Dabke, G, Figureroa, Jose, Hashim, Ahmed B., Nguyen-Van-Tam, JS, Ishola, David A, Peñalver, Javier, Figureroa, J, Mobasher Butt, Mary O'Brien, Hird, C, Laura Béchard-Evans, Harris, Rebecca, Wigglesworth, Neil, Glenda Augustine, Richard Puleston, Ishola, DA, Isba, Rachel, Felix Greaves, Peñalver, J, Sophie Kim, McKenzie, Bruce C., Béchard-Evans, L, Agboado, Gabriel, Weston, Rachel, Orton, Elizabeth, Liz Lingard, Caroline Hird, Stevenson, C, Augustine, Glenda, O'Boyle, J, Hashim, Ahmed B, Dabke, Girija, Rachel Isba, Morgan, Gemma, Theaker, S, Ishola, David A., Kerac, M, O'Brien, Mary, Mitsuru Mukaigawara, Elizabeth Orton, Beck, Charles, Theaker, Sarah, Rosser, Julia, Vinogradova, Yana, Siobhan Farmer, Dean Wallace, Horiuchi, Hiroshi, Weston, R, Vinogradova, Y, Béchard-Evans, Laura, Sophie Haroon, Wallace, D, O'Boyle, Julie, Nguyen-Van-Tam, Jonathan S, Neil Wigglesworth, Haroon, Sophie, Hashim, Ahmed, Helene Denness, Wallace, Dean, Lingard, L, Zanuzdana, Arina, Munib Haroon, McKenzie, Bruce C, Nguyen-Van-Tam, Jonathan, Agboado, G, Horiuchi, H, David A Ishola, Harris, Rebecca C, Gabriel Agboado, Rachel Weston, Yana Vinogradova, Nguyen-Van-Tam, Jonathan S., Robert Howard, Beck, CR, Orton, E, Kim, S, Lauren Ahyow, Jonathan S Nguyen-Van-Tam, Roberts, Jonathan, Fisher, P, Farmer, S, Jonathan Roberts, Ishola, David, Lingard, Liz, Enstone, Joanne, Howard, Robert, Greaves, Felix, Howard, R, Denness, Helene, Isba, R, Fisher, Paul, Enstone, J, Hird, Caroline, Julie O'Boyle, Harris, RC, Haroon, Munib, Mukaigawara, Mitsuru, Rosser, J, Girija Dabke, Arina Zanuzdana, Sarah Theaker, Butt, M, Greaves, F, McKenzie, BC, Ahyow, Lauren, Hashim, AB, Morgan, G, Farmer, Siobhan, Ahmed B Hashim, Charles R Beck, Beck, Charles R, Parish, Vivienne, Julia Rosser, McKenzie, Bruce, O'Brien, M, Roberts, J   +143 more
core   +4 more sources

Enhancement of the Influenza Surveillance System in the Russian Federation: the Main Results of the Sentinel Surveillance for Influenza and other Acute Respiratory Viral Infections

Эпидемиология и вакцинопрофилактика, 2017
Existing influenza surveillance system is constantly improved to obtain comprehensive information for understanding of continuously changing situation with the influenza, which is a consequence of the highest variability of the pathogen, its ability to ...
A. A. Sominina, E. A. Smorodintseva, K. A. Stolyarov, A. A. Mel'nikova   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Pandemic (H1N1) 2009, Shanghai, China

Emerging Infectious Diseases, 2010
To understand the clinical and epidemiologic characteristics of pandemic (H1N1) 2009 virus infection, we retrospectively reviewed medical records of 237 patients with laboratory-confirmed cases reported in Shanghai, China, during May–July 2009 ...
Yinzhong Shen, Hongzhou Lu
doaj   +1 more source

Influenza A H5N1 Replication Sites in Humans

Emerging Infectious Diseases, 2005
Tissue tropism and pathogenesis of influenza A virus subtype H5N1 disease in humans is not well defined. In mammalian experimental models, H5N1 influenza is a disseminated disease. However, limited previous data from human autopsies have not shown evidence of virus dissemination beyond the lung.
Uiprasertkul, M, Puthavathana, P, Nicholls, JM, Peiris, M, Auewarakul, P, Vanprapar, N, Chokephaibulkit, K, Srisook, K, Pooruk, P, Sangsiriwut, K   +9 more
openaire   +4 more sources