Results 41 to 50 of about 1,191,282 (266)

Combining deep learning with statistical shape modelling enables automated lower limb measurements with observer‐level reliability using weight‐bearing computed tomography

Journal of Experimental Orthopaedics
Purpose Accurate anatomical landmarking is crucial for assessing lower limb alignment, diagnosing deformities, planning surgeries and monitoring treatment outcomes.
Ide Van den Borre, Emmanuel Audenaert, Hannes Vermue, Roel Huysentruyt, Leonie Van Vynckt, Robin Vanhauwe, Victor Pas, Aleksandra Pizurica, Aline Van Oevelen   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Collective information processing in human phase separation

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
In our digital societies, individuals massively interact through digital interfaces whose impact on collective dynamics can be important. In particular, the combination of social media filters and recommender systems can lead to the emergence of polarized and fragmented groups. In some social contexts, such segregation processes of
Jayles, Bertrand, Escobedo, Ramon, Pasqua, Roberto, Zanon, Christophe, Blanchet, Adrien, Roy, Matthieu, Trédan, Gilles, Theraulaz, Guy, Sire, Clément   +8 more
openaire   +8 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Passive surveillance of Leptospira infection in swine in Germany

Porcine Health Management, 2018
Background As no current data are available on the prevalence of leptospiral infection in swine in Germany, we analysed laboratory data from diagnostic examinations carried out on samples from swine all over Germany from January 2011 to September 2016. A
Katrin Strutzberg-Minder, Astrid Tschentscher, Martin Beyerbach, Matthias Homuth, Lothar Kreienbrock   +4 more
doaj   +1 more source

Capacity limitations in human information processing [PDF]

Memory & Cognition, 1976
The nature of processing demands during a letter-match task was investigated in an extension of the Posner and Boies (1971) paradigm. In Experiment I, a visual probe was employed in addition to an auditory probe in two different experimental conditions.
openaire   +2 more sources