Results 91 to 100 of about 400,125 (363)

Analysis of non-HLA genomic risk factors in HLA-matched unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia

Haematologica, 2012
Background Allogeneic hematopoietic cell transplantation is the main curative therapy for patients with chronic myeloid leukemia who do not respond to tyrosine kinase inhibitors.
Kim F. Pearce, Stephanie J. Lee, Michael Haagenson, Effie W. Petersdorf, Jean Norden, Matthew P. Collin, John P. Klein, Stephen R. Spellman, Shelagh A. Lowerson, Stella Davies, Anne M. Dickinson   +10 more
doaj   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Overview of Human Leukocyte Antigen Development at Siriraj Hospital

Siriraj Medical Journal, 2017
No ...
Dasnayanee Chandanayingyong
doaj  

Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor [PDF]

, 1995
Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive ...
Fu, F, Fung, JJ, Lu, L, McCaslin, D, Qian, S, Rao, AS, Rudert, WA, Starzl, TE, Thomson, AW, Trucco, M   +9 more
core   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

Haematologica, 2017
Recent studies have suggested that plasma-derived proteins may be potential biomarkers relevant for graft-versus-host disease and/or non-relapse mortality occurring after allogeneic blood or marrow transplantation.
Christopher G. Kanakry, Giorgos Bakoyannis, Susan M. Perkins, Shannon R. McCurdy, Ante Vulic, Edus H. Warren, Etienne Daguindau, Taylor Olmsted, Christen Mumaw, Andrea M.H. Towlerton, Kenneth R. Cooke, Paul V. O’Donnell, Heather J. Symons, Sophie Paczesny, Leo Luznik   +14 more
doaj   +1 more source

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees [PDF]

, 2001
The radiation-attenuated Schistosoma mansoni vaccine is highly effective in rodents and primates but has never been tested in humans, primarily for safety reasons.
Abe K., Agnew A., Amory Soisson L., Aranda-Michel J., Araújo M. I., Ashton P. D., Bergquist N. R., Butterworth A. E., Butterworth A. E., Caldas I. R., Capron A., Carneiro-Santos P., Caulada-Benedetti Z., Chan M. S., Coulson P. S., de Clercq D., de Jonge N., Deelder A. M., Doetze A., Dunne D. W., Eberl M., Eberl M., Eberl M., Gryseels B, Gryseels B., Grzych J. M., Harrop R., Harrop R., Hsü S. Y., Jankovic D., Kardorff R., Kasper G., Katz N., Kuntz R. E., Mahmoud O. M., Malaquias L. C. C., Mansour M. M., Marguerite M., Medhat A., Montenegro S. M. L., Moser D., Olsen A., Omer F. M., Omer-Ali P., Pearce E. J., Pemberton R. M., Polman K., Prince A. M., Renquist D. M., Rieckmann K. H., Rocha M. O., Sadun E. H., Sadun E. H., Sher A., Smythies L. E., Sundstedt A., Tanner M., Velupillai P., Viana I. R., Viana I. R., von Lichtenberg F., von Lichtenberg F., Williams M. E., Wilson R. A., Yole D. S., Yole D. S.   +65 more
core   +2 more sources

Human leukocyte antigens and natural selection by malaria

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1994
The extraordinary polymorphism of human leukocyte antigens (HLA) poses a question as to how this remarkable diversity arose and is maintained. The explanation that infectious pathogens are largely responsible is theoretically attractive but clear and consistent associations between HLA alleles and major infectious diseases have rarely been identified ...
Hill, A, Yates, SN, Allsopp, C, Gupta, S, Gilbert, S, Lalvani, A, Aidoo, M, Davenport, M, Plebanski, M   +8 more
openaire   +4 more sources