Results 111 to 120 of about 8,336,904 (303)

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Investigation of human leukocyte antigen in osteoarticular brucellosis

, 2017
Background/aim: To determine the relationship between human leukocyte antigen (HLA) antigens and osteoarticular brucellosis by evaluating HLA Class I and II antigens in control subjects and patients developing osteoarticular brucellosis in ...
Gönen, S., Sevim GÖNEN, Dizbay, M., Soylemezoglu, Oguz, Söylemezoğlu, O., GÖNEN, SEVİM, Murat DİZBAY, Oğuz SÖYLEMEZOĞLU, DİZBAY, MURAT, SÖYLEMEZOĞLU, HÜSNÜ OĞUZ, Gonen, Sevim and Dizbay, Murat and Soylemezoglu, Oguz   +10 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Crosslinks Between Human Leukocyte Antigen DRB1*01 and Human Leukocyte Antigen DRB1*13 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina

The Turkish Journal of Gastroenterology, 2017
Objectives: This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1*, HLA-DRB3*, HLA-DRB4*, HLA-DRB5*, HLA-DQB1* loci expression in patients with rheumatoid arthritis ...
Elma FEJZIC, Amela SAHOVIC, Sanela SISIC, Andi ALIJAGIC, Damir SULJEVIC   +4 more
doaj  

Supplementary Table S1 from Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell Lymphoma

, 2006
Supplementary Table S1 from Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell ...
Jenny Douwes (14903795), Ed Schuuring (73120), Andreas Rosenwald (321), Daphne de Jong (3622187), Klaas Kok (722694), Ekaterina S. Jordanova (9857063), Marije Booman (3489179), Sietske A. Riemersma (14980369), Philip M. Kluin (14974495), Annuska M. Glas (14972914)   +9 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Clinical data of patients with celiac disease AATG, antitransglutaminase antibody, expressed as U/mL; AAEM, antiendomysial antibody; HLA, human leukocyte antigen; nd, no data.

, 2012
Clinical data of patients with celiac disease AATG, antitransglutaminase antibody, expressed as U/mL; AAEM, antiendomysial antibody; HLA, human leukocyte antigen; nd, no data.
Laura de Lorenzo (110977), Ángel Cebolla (5648710), Miguel Ángel López-Casado (110982), Javier Gil-Humanes (110979), Ana Real (110974), Fernando Pistón (110997), Francisco Merchán (110978), María J. Giménez (110980), Carolina Sousa (110987), Isabel Comino (110975), Francisco Barro (110992)   +10 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Human Leukocyte Antigen Diversity: A Southern African Perspective

Journal of Immunology Research, 2015
Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations.
Mqondisi Tshabalala, Juanita Mellet, Michael S. Pepper   +2 more
doaj   +1 more source

Supplementary Table S2 from Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell Lymphoma

, 2006
Supplementary Table S2 from Mechanisms and Effects of Loss of Human Leukocyte Antigen Class II Expression in Immune-Privileged Site-Associated B-Cell ...
Jenny Douwes (14903795), Ed Schuuring (73120), Andreas Rosenwald (321), Daphne de Jong (3622187), Klaas Kok (722694), Ekaterina S. Jordanova (9857063), Marije Booman (3489179), Sietske A. Riemersma (14980369), Philip M. Kluin (14974495), Annuska M. Glas (14972914)   +9 more
core   +1 more source