Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection [PDF]
Frontiers in Immunology, 2021 Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high association with the presence of human leukocyte antigen (HLA)-B*27.
Chengappa G. Kavadichanda +4 more
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Human leukocyte antigen - HLA B*27: Unraveling the link to pathogenesis
Indian Journal of Rheumatology, 2020 The association of spondyloarthritis (SpA) with human leukocyte antigen-B*27 (HLA-B*27) is one of the strongest known for a non-monogenic disease.
Sakir Ahmed, Ramnath Misra
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HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. [PDF]
PLoS Pathogens, 2020 Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity
Sneha Sant +13 more
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Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review [PDF]
LifeBackground: Non-infectious uveitis (NIU) is an inflammatory ocular condition often associated with systemic immune-mediated disorders. The pathogenesis of NIU is complex and involves genes from the Human Leukocyte Antigen (HLA) class I system ...
Ioana-Maria Rizea +9 more
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Targeted Delivery of the HLA-B∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis [PDF]
Mediators of Inflammation, 2017 Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B∗27). HLA-B∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the ...
Hui-Chun Yu +6 more
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An investigation on significantly higher allele frequency of Human Leucocyte Antigen A, B, C, DR and DQ in Hepatitis B infected patients as compared to the healthy controls by Next Generation Sequencing in Nepalese population [PDF]
Infectious Diseases and Tropical Medicine, 2022 OBJECTIVE: Different Human Leukocyte Antigen (HLA) types are linked with different clinical manifestations of Hepatitis B virus infection. However, the association of HLA with different stages of the Hepatitis B infected population in Kathmandu, Nepal,
S. Shrestha +5 more
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HLA polymorphism and susceptibility to end-stage renal disease in Cantonese patients awaiting kidney transplantation. [PDF]
PLoS ONE, 2014 BACKGROUND: End-Stage Renal Disease (ESRD) is a worldwide public health problem. Currently, many genome-wide association studies have suggested a potential association between human leukocyte antigen (HLA) and ESRD by uncovering a causal relationship ...
Qiong Cao +9 more
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Brazilian Journal of Infectious Diseases, 2021 The interaction of HIV-1, human leukocyte antigen (HLA), and elite controllers (EC) compose a still intricate triad. Elite controllers maintain a very low viral load and a normal CD4 count, even without antiretrovirals. There is a lot of diversity in HIV
Luciano Werle Lunardi +2 more
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EBioMedicine, 2015 Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies.
Stephen A. Migueles +17 more
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Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada. [PDF]
PLoS ONE, 2012 Host immune selection pressure influences the development of mutations that allow for HIV escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA-allele specific.
Manon Ragonnet-Cronin +7 more
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