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Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection [PDF]

open access: yesFrontiers in Immunology, 2021
Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high association with the presence of human leukocyte antigen (HLA)-B*27.
Chengappa G. Kavadichanda   +4 more
doaj   +4 more sources

Human leukocyte antigen - HLA B*27: Unraveling the link to pathogenesis

open access: yesIndian Journal of Rheumatology, 2020
The association of spondyloarthritis (SpA) with human leukocyte antigen-B*27 (HLA-B*27) is one of the strongest known for a non-monogenic disease.
Sakir Ahmed, Ramnath Misra
doaj   +3 more sources

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.

open access: yesPLoS Pathogens, 2020
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity
Sneha Sant   +13 more
doaj   +2 more sources

Association Between Human Leukocyte Antigen-B*27 and Pathogenesis in Seronegative Spondyloarthropathies in Federation of Bosnia and Herzegovina

open access: yesThe Turkish Journal of Gastroenterology, 2019
Objectives: This study aims to investigate the low-resolution human leukocyte antigen (HLA)-B locus polymorphisms between unrelated healthy individuals and patients with diagnosis of seronegative spondyloarthropathies and determine risky and protective ...
Elma FEJZIĆ   +5 more
doaj   +2 more sources

Association of Human Leukocyte Antigen-(HLA-B 27) Gene Polymorphism with Vitiligo Disease

open access: yesIndian Journal of Public Health Research & Development, 2019
Vitiligo have been recorded in different ages in population it is appeared by interaction between different factors causes de-pigmentation in skin, the present study conducted to estimate HLA 27 gene polymorphism in vitiligo patients using single ...
Mona N. Al-Terehi   +4 more
openaire   +2 more sources

Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population

open access: yesIndian Journal of Rheumatology, 2018
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints and spine. Genetic factors play a key role in AS susceptibility.
Vikram Haridas   +6 more
doaj   +2 more sources

A case of human leukocyte antigen B-27-associated ocular hypotony successfully treated with golimumab

open access: yesIndian Journal of Ophthalmology, 2018
A 42-year-old male presented to us after an episode of acute anterior human leukocyte antigen (HLA)-B27-associated uveitis, and intraocular pressure (IOP) in the right eye was 4 mmHg. Ultrasound biomicroscopy revealed ciliary body edema with supraciliary
Parthopratim Dutta Majumder   +4 more
doaj   +2 more sources

Targeted Delivery of the HLA-B∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis

open access: yesMediators of Inflammation, 2017
Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B∗27). HLA-B∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the ...
Hui-Chun Yu   +6 more
doaj   +2 more sources

The rapid detection of human HLA-B*27 gene based on BASIC isothermal detection

open access: yesScientific Reports
Ankylosing spondylitis (AS) is a chronic, inflammatory arthritis of the spine and peripheral joints which is known to have a strong association with the human leukocyte antigen B27 (HLA-B27).
Ying Chen   +9 more
doaj   +2 more sources

Human leukocyte antigen study on a cohort of 149 Vietnamese umbilical cord blood samples [PDF]

open access: yesTzu Chi Medical Journal
Objectives: We here report the distribution of the human leukocyte antigen (HLA)-A, -B, -C, -DRB1, and -DQB1 alleles among 149 units of Vietnamese umbilical cord blood samples and deduced their most probable HLA haplotypes for HLA-A/B loci, HLA-B/C loci,
Kuo-Liang Yang   +4 more
doaj   +2 more sources

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