Results 11 to 20 of about 74,702 (247)

Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort [PDF]

Discover Oncology
Background and aim Host genetic factors, particularly human leukocyte antigen (HLA) polymorphisms, play a crucial role in determining the immunological outcome of Hepatitis C virus (HCV) infection.
Mai M. Lotfy, Noura A. A. Ebrahim, Mohamed El-Kassas, Ashraf Omar Abdel-Aziz, Dalia Abdelhamid Omran, Dalia Abdelfatah, Ahmed B. Barakat, Amira Salah El-Din Youssef, Auhood Nassar, Hany K. Soliman, Abdel Rahman N. Zekri   +10 more
doaj   +2 more sources

Human Leukocyte Antigen B*27-Negative Spondyloarthritis: Clinical, Serological, and Radiological Features of a Single-Center Cohort

Diagnostics, 2023
The strong genetic association between HLA-B*27 and spondyloarthritis (SpA) accounts for about 90% of the susceptibility to axial SpA (axSpA), and the presence of HLA-B*27 is helpful in classifying patients according to the Assessment of ...
F. Mariani, A. Alunno, Evy di Ruscio, Piera Altieri, Claudio Ferri, F. Carubbi   +5 more
semanticscholar   +1 more source

An investigation on significantly higher allele frequency of Human Leucocyte Antigen A, B, C, DR and DQ in Hepatitis B infected patients as compared to the healthy controls by Next Generation Sequencing in Nepalese population [PDF]

Infectious Diseases and Tropical Medicine, 2022
OBJECTIVE: Different Human Leukocyte Antigen (HLA) types are linked with different clinical manifestations of Hepatitis B virus infection. However, the association of HLA with different stages of the Hepatitis B infected population in Kathmandu, Nepal,
S. Shrestha, S. Upadhyay, J. Baniya, M. Sharma, M. Maurya, K. Das Manandhar   +5 more
doaj   +1 more source

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes

International Journal of Molecular Sciences, 2023
The human leukocyte antigen (HLA)-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disorder affecting the axial and peripheral joints, yet some HLA-B*27 variants not associated with AS have been shown.
Valentina Tedeschi, Giorgia Paldino, Josephine Alba, Emanuele Molteni, F. Paladini, R. Scrivo, M. Congia, A. Cauli, R. Caccavale, M. Paroli, M. Di Franco, L. Tuosto, Rosa Sorrentino, M. D’Abramo, M. Fiorillo   +14 more
semanticscholar   +1 more source

HLA polymorphism and susceptibility to end-stage renal disease in Cantonese patients awaiting kidney transplantation. [PDF]

PLoS ONE, 2014
BACKGROUND: End-Stage Renal Disease (ESRD) is a worldwide public health problem. Currently, many genome-wide association studies have suggested a potential association between human leukocyte antigen (HLA) and ESRD by uncovering a causal relationship ...
Qiong Cao, Di Xie, Jiangmei Liu, Hongyan Zou, Yinze Zhang, Hong Zhang, Zhimei Zhang, Hao Xue, Jiyuan Zhou, Pingyan Chen   +9 more
doaj   +1 more source

The influence of HLA/HIV genetics on the occurrence of elite controllers and a need for therapeutics geotargeting view

Brazilian Journal of Infectious Diseases, 2021
The interaction of HIV-1, human leukocyte antigen (HLA), and elite controllers (EC) compose a still intricate triad. Elite controllers maintain a very low viral load and a normal CD4 count, even without antiretrovirals. There is a lot of diversity in HIV
Luciano Werle Lunardi, Marcelo Alves de Souza Bragatte, Gustavo Fioravanti Vieira   +2 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

CD8+ T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types

EBioMedicine, 2015
Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies.
Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, Mark Connors   +17 more
doaj   +1 more source

Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada. [PDF]

PLoS ONE, 2012
Host immune selection pressure influences the development of mutations that allow for HIV escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA-allele specific.
Manon Ragonnet-Cronin, Stéphane Aris-Brosou, Isabelle Joanisse, Harriet Merks, Dominic Vallee, Kyna Caminiti, Paul Sandstrom, James Brooks   +7 more
doaj   +1 more source

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS Genetics, 2020
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human ...
Aimee L Hanson, International Genetics of Ankylosing Spondylitis Consortium, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown   +7 more
doaj   +1 more source