Results 31 to 40 of about 70,114,613 (255)

HLA Preferences for Conserved Epitopes: A Potential Mechanism for Hepatitis C Clearance

Frontiers in Immunology, 2015
Hepatitis C virus (HCV) infections affect more than 170 million people worldwide. Most of these individuals are chronically infected, but some clear the infection rapidly.
Xiangyu eRao, Ilka eHoof, Debbie eVan Baarle, Debbie eVan Baarle, Can eKeşmir, Johannes eTextor   +5 more
doaj   +1 more source

Human leukocyte antigen-B alleles in spondyloarthritides: A single-center, prospective, cross-sectional study

Indian Journal of Rheumatology, 2022
Objective: The objective of this study is to study distribution of human leukocyte antigen (HLA)-B alleles in Spondyloarthritis (SpA) and to find its clinical relevance in the patient management.
Jeet Hemantkumar Patel, Ved Chaturvedi, Lalit Duggal, Neeraj Jain, Gurbir Bhandari, Monika Jain   +5 more
doaj   +1 more source

Comparative Molecular Analysis and Antigenicity Prediction of an Outer Membrane Protein (ompC) of Non-typhoidal Serovars Isolated from Different Food Animals in Lagos, Nigeria

Bioinformatics and Biology Insights, 2023
Non-typhoidal Salmonella (NTS) infections occur globally with high morbidity and mortality. The public health challenge caused is exacerbated by increasing rate of antibiotic resistance and absence of NTS vaccine.
Morufat Yusuf, Abraham Ajayi, Utibeima Udo Essiet, Oyin Oduyebo, Adeyemi Isaac Adeleye, Stella Ifeanyi Smith   +5 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Maboko Leonard, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Eller Michael, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +44 more
core   +2 more sources

The Immunological Epigenetic Landscape of the Human Life Trajectory

Biomedicines, 2022
Adaptive immunity changes over an individual’s lifetime, maturing by adulthood and diminishing with old age. Epigenetic mechanisms involving DNA and histone methylation form the molecular basis of immunological memory during lymphocyte development ...
Iva Juříčková, Michael Hudec, Felix Votava, Jan Vosáhlo, Saak Victor Ovsepian, Marie Černá, Valerie Bríd O’Leary   +6 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

High sensitivity of human leukocyte antigen–B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients [PDF]

, 2008
Background. Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to abacavir (ABC), variable sensitivities have been reported when clinical data alone have been used to define an ABC HSR.
Stancil, B., Balu, R., Mosteller, M., Wannamaker, P., Phillips, E.J., Saag, M., Burman, W., Brothers, C., Brachman, P., Hughes, A., Sutherland‐Phillips, D., Martorell, C., Mallal, S., Shaefer, M.   +13 more
core  

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source