Results 21 to 30 of about 70,114,613 (255)

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis.

PLoS Genetics, 2020
The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells, are a collection of highly polymorphic activating and inhibitory receptors with variable specificity for class I human ...
Aimee L Hanson, International Genetics of Ankylosing Spondylitis Consortium, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Lê Cao, Tony J Kenna, Matthew A Brown   +7 more
doaj   +1 more source

HLA‐B27 association of autoimmune encephalitis induced by PD‐L1 inhibitor

Annals of Clinical and Translational Neurology, 2020
Objective While immune checkpoint inhibitors are increasingly used for various cancers, unpredictable immune‐related adverse events (irAEs) such as autoimmune encephalitis is life‐threatening.
Hyeyeon Chang, Yong‐Won Shin, Bhumsuk Keam, Miso Kim, Seock‐Ah Im, Soon‐Tae Lee   +5 more
doaj   +1 more source

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes [PDF]

, 2023
The human leukocyte antigen (HLA)-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disorder affecting the axial and peripheral joints, yet some HLA-B*27 variants not associated with AS have been shown.
Tuosto L., Alba J., Tedeschi V., Cauli A., Caccavale R., Sorrentino R., D'Abramo M., Paroli M., Paladini F., Congia M., Scrivo R., D’Abramo M., Fiorillo M. T., Paldino G., Di Franco M., Molteni E., Mattia Congia, Emanuele Molteni, Rosalba Caccavale, Manuela Di Franco, Giorgia Paldino, Marco D’Abramo, Josephine Alba, Maria Teresa Fiorillo, Loretta Tuosto, Rossana Scrivo, Rosa Sorrentino, Marino Paroli, Fabiana Paladini, Alberto Cauli, Valentina Tedeschi   +30 more
core   +2 more sources

Tumor-Specific CircRNA-Derived Antigen Peptide Identification for Hepatobiliary Tumors

Engineering, 2023
The application of tumor antigen-based immunotherapy is hindered by the rarity of validated immunogenic peptides. In this study, we aimed to investigate the potential of circular RNAs (circRNAs) as a novel source of tumor antigen peptides in ...
Wenwen Wang, Lili Ma, Zheng Xing, Tinggan Yuan, Jinxia Bao, Yanjing Zhu, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Siyun Shen, Xinyao Qiu, Shuai Yang, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen   +16 more
doaj   +1 more source

A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis

Vaccines, 2022
Subacute thyroiditis (SAT) is a thyroid disease associated with viral infections. Its relationship with major histocompatibility complex (MHC) antigens was shown before.
Melisa Sahin Tekin, Goknur Yorulmaz, Emel Yantir, Eren Gunduz, Ertugrul Colak   +4 more
doaj   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source

FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte
Sardar Muhammad, Amer Fakhr, Muhammad Adnan Manzar, Farzana Hakim, Taimoor Ashraf Khan, Bilal Ahmad   +5 more
doaj   +4 more sources

A melanoma immune response signature including Human Leukocyte Antigen-E

, 2014
Paired cultures of early-passage melanoma cells and melanocytes were established from metastatic lesions and the uninvolved skin of five patients. In this stringent autologous setting, cDNA profiling was used to analyze a subset of 1477 genes selected by
Benassi, B.
core   +2 more sources