Results 51 to 60 of about 70,114,613 (255)

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Prevalence of HLA-B*27 subtypes in ethnic Tamil population of India with Ankylosing Spondylitis [PDF]

, 2018
INTRODUCTION: The Human leukocyte antigen-B*27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with Ankylosing spondylitis (AS).
Snehil Kumar,
core  

Evaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypes

Cell Transplantation, 2010
For human embryonic stem cells (hESCs) to be used clinically, it is imperative that immune responses evoked by hESCs and their derivates after transplantation should be prevented.
Jeoung Eun Lee, Myung Seo Kang, Myoung Hee Park, Sung Han Shim, Tae Ki Yoon, Hyung Min Chung, Dong Ryul Lee Ph.D.   +6 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

HLA-B*5701 screening for hypersensitivity to Abacavir [PDF]

, 2008
Background Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to ...
Jagel-Guedes, E., Kozyrev, O., Phillips, E., Fitch, N., Thorborn, D., Molina, J-M, Hughes, A., Cid, J.F., Rugina, S., Nolan, D., Carosi, G., Hay, P., Ryan, S., Tomazic, J., Hughes, S., Benbow, A., Mallal, S., Workman, C.   +17 more
core  

Association Between Human Leukocyte Antigen-B*27 and Pathogenesis in Seronegative Spondyloarthropathies in Federation of Bosnia and Herzegovina

The Turkish Journal of Gastroenterology, 2019
Objectives: This study aims to investigate the low-resolution human leukocyte antigen (HLA)-B locus polymorphisms between unrelated healthy individuals and patients with diagnosis of seronegative spondyloarthropathies and determine risky and protective ...
Elma FEJZIĆ, Izet EMINOVIĆ, Jasenko KARAMEHIĆ, Amela ŠAHOVIĆ, Sanela ŠIŠIĆ, Damir SULJEVIĆ   +5 more
doaj  

Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different Severities

Frontiers in Immunology, 2022
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in the progression stage, a detailed understanding of pertinent immune cells in recovered patients is lacking.
Xu Li, Manik Garg, Tingting Jia, Qijun Liao, Lifang Yuan, Mao Li, Zhengyu Wu, Weihua Wu, Yalan Bi, Nancy George, Irene Papatheodorou, Alvis Brazma, Huanle Luo, Shisong Fang, Zhichao Miao, Zhichao Miao, Yuelong Shu   +16 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis

Iranian Journal of Allergy, Asthma and Immunology, 2008
The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS).
Mohamad Hossein Nicknam, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mazdak Ganjalikhani Hakemi, Farideh Khosravi, Ahmad Reza Jamshidi, Aref Amirkhani, Bita Ansaripour, Zahra Pourpak, Mostafa Moin, Behrooz Nikbin   +10 more
doaj  

Frequency of HLA-A, -B, -DRB1, and -DQB1 Alleles in Moroccan Adult Patients with Acute Myeloid Leukemia: A Case–Control Study

BioChem
Background/Objectives: Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with over 50% of individuals succumbing to the disease annually.
Khalid Laaziri, Abdelmajid Zyad, Fatima Ezzahra Lahlimi, Ouadii Abakarim, Illias Tazi, Ikram Brahim, Nadia Lakhouaja, Raja Hazime, El Mostafa Mtairag, Brahim Admou   +9 more
doaj   +1 more source