Results 61 to 70 of about 70,114,613 (255)

Association of Human Leukocyte Antigen (HLA) B-27 Polymorphism with Risk of Diabetes Type one among Patients Visiting Gondar University Teaching Hospital

, 2017
No abstract available for this ...
openaire   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Human leukocyte antigen (HLA) B-27 and older age are associated with augmented cyclosporine blood bioavailability in renal allograft recipients: an attempt toward individualization of immunosuppression.

Annals of transplantation, 2009
Therapeutic drug monitoring of cyclosporine (CsA) blood values in renal transplant recipients is of extreme importance; hence, finding contributing factors in this issue is relevant. In this study, we aimed to evaluate potential associations of some characteristics of the recipients including their human leukocyte antigen haplotypes with their drug ...
Eghlim, Nemati, Saeed, Taheri, Vahid, Pourfarziani, Behzad, Einollahi   +3 more
openaire   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

, 2019
Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear.
Bowness, Paul, Max J. Cryle, Greule, Anja, Terry C.C. Lim Kam Sian, Saranjah Indumathy, Stephanie Gras, Jamie Rossjohn, Purcell, Anthony W., Paul Bowness, Indumathy, Saranjah, Anthony W. Purcell, Halim, Hanim, Gras, Stephanie, Rossjohn, Jamie, Ralf B. Schittenhelm, Lim Kam Sian, Terry C. C., Anja Greule, Schittenhelm, Ralf B., Hanim Halim, Cryle, Max J.   +19 more
core   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

The Oxidative Folding and Misfolding of Human Leukocyte Antigen-B27

, 2011
The major histocompatibility complex class I molecule human leukocyte antigen (HLA)-B27 is strongly associated with a group of inflammatory arthritic disorders known as the spondyloarthropathies.
Guiliano, D.B., Powis, S.J., Burn, G., Antoniou, A.N., Lenart, I.   +4 more
core   +2 more sources

Pattern of uveitis in a tertiary eye care center in Western India

Journal of Clinical Ophthalmology and Research, 2017
Context: Uveitis is potentially sight-threatening disease. The age-sex adjusted prevalence of uveitis in India is 0.73%. Few studies from South and North India have reported the pattern of uveitis but none from Western India.
Aratee C Palsule, Vaidehi Jande, Aditi A Kulkarni, Nikhil N Beke   +3 more
doaj   +1 more source

HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer. [PDF]

PLoS ONE, 2014
OBJECTIVE: Enhancing immunologic responses, including human leukocyte antigen (HLA) class I expression on tumor cells and recognition and elimination of tumor cells by tumor-specific cytotoxic T lymphocyte (CTL), is considered a novel concept of ...
Hiro Sato, Yoshiyuki Suzuki, Munenori Ide, Toshihide Katoh, Shin-Ei Noda, Ken Ando, Takahiro Oike, Yuya Yoshimoto, Noriyuki Okonogi, Kousaku Mimura, Takayuki Asao, Hiroyuki Kuwano, Takashi Nakano   +12 more
doaj   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source