Results 81 to 90 of about 70,114,613 (255)

Association Between HLA Polymorphisms and Non-Alcoholic Fatty Liver Disease in Patients with Rheumatoid Arthritis: An Observational Study

Diseases
Background/Objectives: This observational study investigated associations between human leukocyte antigen (HLA) polymorphisms and imaging-defined hepatic steatosis (non-alcoholic fatty liver disease—NAFLD) and liver fibrosis in patients with rheumatoid ...
Tatjana Zekić, Nataša Katalinić, Filip Blažić, Nada Starčević Čizmarević, Aleksandar Čubranić   +4 more
doaj   +1 more source

Distribution of HLA-A, -B, and -C Alleles and HLA/KIR Combinations in Han Population in China

Journal of Immunology Research, 2014
We investigated polymorphisms of the human leukocyte antigen (HLA) class I (A, B, and C) loci of a Han population (n, 239) from the Yunnan province, Southwest China, using high-resolution polymerase chain reaction-Luminex (PCR-Luminex) typing.
Yunsong Shen, Danfeng Cao, Yalin Li, J. K. Kulski, Lei Shi, Hongjun Jiang, Qianli Ma, Jiankun Yu, Jingxian Zhou, Yufeng Yao, Li Shi   +10 more
doaj   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure

Medeniyet Medical Journal
Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD
Burcu KARAKUS TURAN, Fahri UCAR, Vural Taner YILMAZ, Yahya KILINC, Sule DARBAŞ ARAS, Huseyin KOCAK, Nurten SAYIN EKINCI, Bulent AYDINLI, Habibe Sema ARSLAN   +8 more
doaj   +1 more source

Focus on the spondyloarthritides. Can earlier diagnosis change the course of the disease?

Italian Journal of Medicine, 2013
The spondyloarthritides (or spondyloarthropathies) (SPAs) are chronic, inflammatory, rheumatic diseases of unknown origin, which share certain clinical, epidemiological, and genetic characteristics. They include ankylosing spondylitis, reactive arthritis
Domenico Galasso, Giovanni Forte, Norma Marigliano   +2 more
doaj   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Association of HLA-B*51:01 and T cell proliferation in Behçet’s disease.

, 2019
Lymphocyte proliferative responses in Behçet's disease induced by four peptides (HSP65, B51PD, MICA-TM, and Topo1PD) were compared between human leukocyte antigen (HLA)-B*51-positive patients and HLA-B*51:01-negative patients.
Youichiro Hamasaki (7377944), Supot Hannongbua (791381), Toshikatsu Kaburaki (153465), Kimiko Okinaga (7377941), Hisae Nakahara (7377938), Fujio Takeuchi (791380), Thanyada Rungrotmongkol (791377), Makoto Aihara (153475), Hiroshi Noguchi (610885), Rie Tanaka (52802), Hidetoshi Kawashima (153503)   +10 more
core   +1 more source

Análisis de genotipos, alelos y haplotipos de HLA en un grupo de pacientes con artritis psoriásica: poca frecuencia de alelos comunes

Biomédica: revista del Instituto Nacional de Salud
Introducción. La artritis psoriásica es una enfermedad compleja y los antígenos leucocitarios humanos (Human Leukocyte Antigen, HLA) son un factor clave en el desarrollo de la enfermedad.
Omar-Javier Calixto, María-Alejandra Meneses-Toro, Paula Andrea Chacón, Mónica Acevedo-Godoy, Luisa Constanza Robayo, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano, Verónica Noguera, Jaime Cortés, Consuelo Romero-Sánchez   +9 more
doaj   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source