Results 101 to 110 of about 70,114,613 (255)

Amino acid substitutions within HLA-B*27- restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells [PDF]

, 2018
Virus-specific CD8 T cell response seems to play a significant role in the outcome of hepatitis delta virus (HDV) infection. However, the HDV-specific T cell epitope repertoire and mechanisms of CD8 T cell failure in HDV infection have been poorly ...
Alavian, S.M., Heiner Wedemeyer, Buti, M., Hofmann, M., Julian Schulze zur Wiesch, Maria Buti, van Esch, W.J.E., Homs, M., Bauer, T., Antes, I., Muthamia M. Kiraithe, David Tabernero, Bijan Raziorrouh, Iris Antes, Kosinska, A.D., Bettina Budeus, Karimzadeh, H., Rizzetto, M., Juk Yee Mok, Anna D. Kosinska, Maria Homs, Mario Rizzetto, Oberhardt, V., Heinold, A., Antonina Smedile, Nguyen, M., Grabowski, J., Olivero, A., Hoffmann, D., Jörg Timm, Melanie Fiedler, Hadi Karimzadeh, Tanja Bauer, Ulrike Protzer, Melanie Nguyen, Keyvani, H., Alizei, E.S., Raziorrouh, B., Smedile, A., Mok, J.Y., Protzer, U., Seyed Moayed Alavian, Budeus, B., Wiesch, J.S., Kiraithe, M.M., Roggendorf, M., Rodríguez-Frías, F., Timm, J., Glaser, M., Tabernero, D., Elahe Salimi Alizei, Neumann-Haefelin, C., Valerie Oberhardt, Francisco Rodríguez-Frías, Antonella Olivero, Wedemeyer, H., Hossein Keyvani, Andreas Heinold, Wim J. E. van Esch, Maike Hofmann, Jan Grabowski, Daniel Hoffmann, Christoph Neumann-Haefelin, Manuel Glaser, Michael Roggendorf, Fiedler, M.   +65 more
core   +1 more source

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.

PLoS Genetics, 2019
Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA effects is extremely challenging.
Julio E Molineros, Loren L Looger, Kwangwoo Kim, Yukinori Okada, Chikashi Terao, Celi Sun, Xu-Jie Zhou, Prithvi Raj, Yuta Kochi, Akari Suzuki, Shuji Akizuki, Shuichiro Nakabo, So-Young Bang, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung-Cheol Shim, Shin-Seok Lee, Xiaoxia Zuo, Kazuhiko Yamamoto, Quan-Zhen Li, Nan Shen, Lauren L Porter, John B Harley, Kek Heng Chua, Hong Zhang, Edward K Wakeland, Betty P Tsao, Sang-Cheol Bae, Swapan K Nath   +32 more
doaj   +1 more source

Ancient genomics study reveals low HLA diversity in eastern hunter-gatherers

Genome Biology
Background Eastern hunter-gatherers (EHG) contributed varying proportions of genetic ancestry to many modern Europeans. However, how this contribution shaped the human leukocyte antigen (HLA) gene diversity remains unexplored.
Onur Özer, Nicolas Antonio da Silva, Magdalena Haller-Caskie, Daniel Anton Myburgh, Henny Piezonka, Anastasia Khramtsova, Elena L. Kostyleva, Maria V. Dobrovol’skaya, Sergei V. Vasilyev, Elizaveta Veselovskaya, John Meadows, Almut Nebel, Ben Krause-Kyora   +12 more
doaj   +1 more source

Histocompatibility HLA class I in anterior uveitis patients with and without spondyloarthritis

Современная ревматология, 2018
Anterior uveitis (AU) and ankylosing spondylitis (AS) are associated with histocompatibility human leukocyte antigen (HLA)-B27. Previous genetic studies conducted in different populations have also demonstrated other genetic associations, including HLA ...
I. A. Guseva, A. A. Godzenko, I. Yu. Razumova   +2 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Antihypertensive drug-induced liver injury is rare, but strongly associated with HLA-B∗35:01

Acta Pharmaceutica Sinica B
Anti-hypertensive (anti-HTN) drugs are widely prescribed, but the features of associated drug-induced liver injury (DILI) are poorly defined. A total of 2207 patients enrolled in the Drug-Induced Liver Injury Network (DILIN) from 2003 to 2024 were ...
Lily Dara, Paola Nicoletti, Chaudry Nasir Majeed, Andrew Dellinger, David E. Kleiner, Mahmoud G. Mohamed, Tatyana Kushner, Raj Vuppalanchi, Elizabeth J Phillips, David A. Ostrov, Mohammed Umair Masood, Huiman Barnhart, Jiezhun Gu, Herbert L. Bonkovsky   +13 more
doaj   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Identification of a novel HLA-B allele, HLA-B*3580, with possible implication in transplantation and CTL response.

, 2008
A new human leukocyte antigen (HLA)-B allele, named B*3580, with an amino acid substitution at residue 156, has been identified during the sequence-based typing of a patient waiting for a hematopoietic cell ...
Adorno D, Piancatelli D, Liberatore G, Aureli A, Papola F   +4 more
core   +1 more source

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source

HLA-B*1832, a novel B allele was found through high-resolution HLA typing of a Spanish blood donor.

, 2009
In this paper, we describe the novel human leukocyte antigen (HLA)-B*1832 allele that we found in a female Spanish volunteer blood donor for clinical investigation during her high-resolution HLA typing.
Witter, K;Conrad, H;Bernhard, H;Albert, T;Kauke, T, K. Witter, H. Bernhard, T. Kauke, T. Albert, H. Conrad   +5 more
core   +1 more source