Results 111 to 120 of about 74,702 (247)

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Cerebrospinal fluid orexin testing in Australians with narcolepsy type 1

Internal Medicine Journal, EarlyView.
Abstract A clinical diagnosis of narcolepsy type 1 can be challenging, particularly in relation to cataplexy. Despite its specificity, cerebrospinal fluid (CSF) orexin testing is under‐utilised in Australasia. We describe the use of CSF orexin testing in 15 clinically indicated patients from two sleep centres, highlighting its utility in the ...
Mario Fernando, Gianluca Cotta, Samantha Kung, Grace Garden, Jian Eu Tai, Elie Matar, Brendon Yee, Claire Ellender, Sheila Sivam   +8 more
wiley   +1 more source

Characterisation of HIV‐1 Gag Cytotoxic T‐Lymphocyte Epitopes in the Southern African Region—A Systematic Review

Immunology, EarlyView.
Distribution of studies on HIV‐1 Gag cytotoxic T‐lymphocyte epitopes in the southern African region showing that the majority of studies (58.44%) were conducted in South Africa, followed by Botswana (15.58%), Zambia (10.39%), Malawi (7.79%), Zimbabwe (6.49%), and Angola (1.30%).
Tumelo L. Fortuin, Paballo Nkone, Shayne Loubser, Caroline T. Tiemessen, Simnikiwe H. Mayaphi   +4 more
wiley   +1 more source

Prognostic prediction models for psoriatic arthritis in psoriasis: A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review evaluated prognostic prediction models used to assess the risk of future psoriatic arthritis in psoriasis patients. The included studies reported modest to moderate performance measures, with limited external validation, inadequate reporting and high risk of bias.
Fatimah Khoda, Yasmin Khan, William W. Y. Haw, Sayeda Nahar, Claire Hodkinson, Hector Chinoy, Richard B. Warren, Glen P. Martin, Zenas Z. N. Yiu   +8 more
wiley   +1 more source

Trimethoprim/sulfamethoxazole-triggered drug-induced hypersensitivity syndrome in an HLA B*13:01-positive kidney transplant recipient: a case report with implications for HLA-severe cutaneous adverse reaction associations in transplant care. [PDF]

CEN Case Rep
Tomizawa M, Hori S, Inoue K, Yoneda T, Akioka N, Nishimura Y, Asada H, Nakai Y, Miyake M, Fujimoto K.   +9 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Interleukin-1 receptor antagonist autoantibodies in Still's disease: Mechanistic insights and laboratory testing. [PDF]

World J Methodol
Bouayad A.
europepmc   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

In Silico-Identified Peptides of Five <i>Borrelia burgdorferi</i> Proteins Binding with High Affinity to Human Leukocyte Antigen (HLA) Class II Alleles. [PDF]

Biology (Basel)
Georgopoulos AP, James LM, Sanders M.
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source