Results 121 to 130 of about 70,114,613 (255)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Abdominal Normothermic Regional Perfusion Versus Normothermic Machine Perfusion of DCD Kidneys Aged 50 Years or Older: A Propensity Score Matched Analysis

Artificial Organs, EarlyView.
This study compares abdominal normothermic regional perfusion (aNRP) and normothermic machine perfusion (NMP) for kidney transplants from older donation after circulatory death (DCD) donors. Both techniques showed similar outcomes in delayed graft function, primary non‐function, acute rejection, and long‐term kidney function, suggesting they may ...
J. S. Slagter, E. F. van de Geijn, F. H. C. de Goeij, P. C. Groen, I. J. Schurink, I. P. J. Alwyn, R. J. Porte, V. A. L. Huurman, J. de Jonge, R. C. Minnee   +9 more
wiley   +1 more source

The Anti‐Inflammatory Effect of Normothermic Machine Perfused Human Kidneys on Monocyte‐Derived Dendritic Cells

Artificial Organs, EarlyView.
The immunogenicity of donor kidneys on NMP can be studied using monocyte‐derived dendritic cells. Incubation with perfusate showed an anti‐inflammatory dendritic cell phenotype and function that suggests the release of an anti‐inflammatory factor or factors during NMP. ABSTRACT Background The immunomodulatory activity of normothermic machine perfusion (
Laura W. D. Knijff, Asel S. Arykbaeva, Sandra W. van der Kooij, Dorottya K. de Vries, Mieke F. van Essen, Ian P. J. Alwayn, Henri G. D. Leuvenink, Rutger J. Ploeg, Cees van Kooten   +8 more
wiley   +1 more source

Prospective phase I study of nivolumab to promote graft‐versus‐tumour in relapsed or refractory haematological malignancy post allogeneic haematopoietic stem cell transplantation

British Journal of Haematology, EarlyView.
Baseline immunophenotype and gene expression predict suitability for salvage nivolumab in patients with relapsed/refractory haematological malignancy. Summary Allogeneic haematopoietic stem cell transplantation (alloHSCT) relies on donor‐derived T cells to mediate the graft‐versus‐tumour (GVT) effect, but relapse may result from impaired immune ...
Trung Q. Ngo, Eric Wong, Joanne E. Davis, Mandy Ludford‐Menting, Jessica Klass, Sara K. Dohrmann, Rachel Koldej, David Ritchie   +7 more
wiley   +1 more source

Molecular mechanism of the susceptibility difference between HLA-B*27:02/04/05 and HLA-B*27:06/09 to ankylosing spondylitis: substitution analysis, MD simulation, QSAR modelling, and in vitro assay

, 2016
The human leukocyte antigen HLA-B27 is directly involved in the disease pathogenesis of ankylosing spondylitis (AS). HLA-B27 has a high degree of genetic polymorphism, with 105 currently known subtypes; the presence of aspartic acid at residue 116 ...
X. Cheng (537654), Q. Xue (2807914), D. Chen (2807917), Y. Mei (2807908), X. Ji (2807911)   +4 more
core   +1 more source

Immunogenetic variations in HIV serotypes in patients attending military hospital, Warri, Nigeria

Egyptian Journal of Medical Human Genetics
Background Human Immunodeficiency Virus (HIV) remains a significant public health concern in Nigeria, characterized by the coexistence of diverse serotypes, mainly HIV-1 and HIV-2, each presenting unique therapeutic challenges.
Mathew Folaranmi Olaniyan, Pius Omoruyi Omosigho, Ferdinand Uwaifo, Tolulope Busayo Olaniyan, Ademola Lukman Adepoju, Odekunle Bola Odegbemi   +5 more
doaj   +1 more source

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma

Brain Pathology, EarlyView.
Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza, Xuan Wang, August Lin, Eric Liu, Pramath Kakodkar, Yayuan Zhao, Quinn Le, Christina A. Castellani, Qi Zhang   +8 more
wiley   +1 more source

Amygdala vulnerability in Pick disease with discrete frontotemporal dementia syndromes

Brain Pathology, EarlyView.
Clinicopathological characterization of the amygdala in FTLD‐tau. Amygdala vulnerability in FTLD‐tauopathies is defined by elevated neuroinflammation and tau in 3R versus 4R subtypes, and greater neuroinflammation in bvFTD versus PPA. In Pick disease, bvFTD and PPA converge neuropsychiatrically over time, and intracellular tau correlates with increased
Rachel Keszycki, Allegra Kawles, Grace Minogue, Antonia Zouridakis, Alyssa Macomber, Caroline Nelson, Qinwen Mao, Rudolph J. Castellani, Pouya Jamshidi, Nathan Gill, Sandra Weintraub, M.‐Marsel Mesulam, Changiz Geula, Tamar Gefen   +13 more
wiley   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source