Results 121 to 130 of about 291,154 (262)

Clinical Predictors of Response in Chronic Graft‐Versus‐Host Disease: Results From the “Predicting the Quality of Response to Specific Treatments (PQRST)” Trial

American Journal of Hematology, EarlyView.
ABSTRACT Despite significant progress in chronic GVHD therapies, challenges remain in understanding pleomorphic phenotypes and varying responses to treatment. The aim of this study was to identify predictors of treatment response. We conducted a prospective, observational cohort study of patients beginning first‐, second‐, or third‐line systemic ...
Betty K. Hamilton, Lynn Onstad, Paul A. Carpenter, Joseph Pidala, George Chen, Corey Cutler, Najla El Jurdi, Nosha Farhadfar, Mark Juckett, Carrie L. Kitko, Catherine J. Lee, Stephanie J. Lee   +11 more
wiley   +1 more source

Association of human leukocyte antigen B genotypes with COVID-19 severity in Egyptian patients. [PDF]

Sci Rep
Abdelmonem R, Selim H, Abdullah Mohamed S, Amponsah RD, Nabil Roshdy M, Hassan Hashish M.   +5 more
europepmc   +1 more source

Dordaviprone Maintenance After Allogeneic HCT for High‐Risk Acute Myeloid Leukemia and Myelodysplastic Neoplasm

American Journal of Hematology, EarlyView.
ABSTRACT Dordaviprone is a first‐in‐class small‐molecule imipridone. In preclinical studies, it is active against leukemia cells harboring a TP53 mutation or complex karyotype and leukemia stem cells while sparing normal bone marrow cells. This study aimed to determine the safety of dordaviprone maintenance after allogeneic hematopoietic cell ...
Vijaya Raj Bhatt, Christopher S. Wichman, Alyssa Bouska, Moataz Ellithi, Michael Haddadin, Javeed Iqbal, James E. Talmadge, Lori J. Maness, Krishna Gundabolu   +8 more
wiley   +1 more source

Human leukocyte antigen study on a cohort of 149 Vietnamese umbilical cord blood samples. [PDF]

Tzu Chi Med J
Yang KL, Phu CD, Chen SP, Wen SH, Lin PY.   +4 more
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Recipient Human Leukocyte Antigen-DR Homozygosity and Access to Quality Kidneys. [PDF]

Kidney Int Rep
Brosi DN, Lopez R, Arrigain S, LaVanchy R, Agrawal A, Isaacson D, Tambur AR, Schold JD.   +7 more
europepmc   +1 more source

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source

Human Leukocyte Antigen-G is enriched in presence of trypanosome in the dermis of individuals exposed to gambiense Human African Trypanosomiasis in Guinea and Côte d'Ivoire. [PDF]

PLoS Negl Trop Dis
Lagrave A, Camara A, Gineau L, Tichit M, Gnankou FB, Soumah AM, Camara M, N'Djetchi M, Kaboré JW, Camara O, Coulibaly B, Sépé B, Nanan V, Kouadio KAM, N'Dri L, Konan T, Milet J, Boiro S, Travaillé C, Crouzols A, Petiot N, Ilboudo H, Hardy D, Sadissou I, Bart JM, Camara M, Kaba D, Koffi M, Bucheton B, Jamonneau V, Courtin D, Rotureau B.   +31 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Human leukocyte antigen-incompatible living donor kidney transplantation after desensitization: experience from a major transplant centre in Mexico. [PDF]

Transpl Int
Reynoso de la Torre HL, Rojas-Campos E, Cerrillos-Gutiérrez JI, Evangelista-Carrillo LA, Banda-López A, Cruz-Landino M, Aguilar-Fletes LE, González-Correa LG, Alatorre-Moreno EV, Simancas-Ruiz PE, Salazar López CB, Miranda-Díaz AG, Sutto ST, Cardona Muñoz EG, Carvallo-Venegas M, Mendoza-Cabrera S, Mendoza Cerpa CA, Romo-Álvarez C, Arellano-Arteaga KJ, Andrade-Sierra J.   +19 more
europepmc   +1 more source