Results 91 to 100 of about 8,336,904 (303)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide [PDF]

, 2017
Recent studies have suggested that plasma-derived proteins may be potential biomarkers relevant for graft-versus-host disease and/or non-relapse mortality occurring after allogeneic blood or marrow transplantation.
Sophie Paczesny, Christen Mumaw, O’Donnell, Paul V., Edus H. Warren, Etienne Daguindau, Towlerton, Andrea M.H., Susan M. Perkins, Taylor Olmsted, Olmsted, Taylor, Paczesny, Sophie, Giorgos Bakoyannis, Cooke, Kenneth R., Bakoyannis, Giorgos, Ante Vulic, Heather J. Symons, Perkins, Susan M., Andrea M.H. Towlerton, Christopher G. Kanakry, Shannon R. McCurdy, Symons, Heather J., Kenneth R. Cooke, Vulic, Ante, Daguindau, Etienne, McCurdy, Shannon R., Kanakry, Christopher G., Paul V. O’Donnell, Luznik, Leo, Leo Luznik, Warren, Edus H., Mumaw, Christen   +29 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Human leukocyte antigens in Turkish pediatric celiac patients

The Turkish Journal of Pediatrics, 1999
With the aim to determine the frequency of human leukocyte antigen phenotypes of celiac disease in Turkey, thirty celiac patients fulfilling the European Society of Pediatric Gastroenterology and Nutrition criteria were included in the study.
T Erkan, T Kutlu, E Yilmaz, F Cullu, G T Tümay   +4 more
doaj  

The human leukocyte antigen region and colorectal cancer risk

, 2005
PURPOSE: Recently, we found a certain haplotype in the human leukocyte antigen Class III subregion to be associated with breast cancer. Epidemiologic studies have shown that breast cancer and colorectal cancer have several risk factors in common. In view
te Meerman, GJ, Kleibeuker, JH, Bruinenberg, M, Sijmons, RH, Hofstra, RMW, Niens, M, van der Graaf, WTA, Schaapveld, M, Nolte, Ilja; id_orcid, de Vries, EGE; id_orcid, Nolte, Ilja, van der Steege, G, de Vries, EGE, Mulder, MJ, de Jong, Mirjam   +14 more
core   +1 more source

In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue [PDF]

, 2009
Directional migration of transmigrated leukocytes to the site of injury is a central event in the inflammatory response. Here, we present an in vivo chemotaxis assay enabling the visualization and quantitative analysis of subtype-specific directional ...
Alexander Georg Khandoga, Peter Bihari, Khandoga, Andrej, Reichel, Christoph Andreas, Rehberg, Markus, Fritz Krombach, Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Krombach, Fritz, Khandoga, Alexander Georg, Andrej Khandoga   +11 more
core   +2 more sources

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Predicting Antigen Presentation—What Could We Learn From a Million Peptides?

Frontiers in Immunology, 2018
Antigen presentation lies at the heart of immune recognition of infected or malignant cells. For this reason, important efforts have been made to predict which peptides are more likely to bind and be presented by the human leukocyte antigen (HLA) complex
David Gfeller, David Gfeller, Michal Bassani-Sternberg, Michal Bassani-Sternberg   +3 more
doaj   +1 more source

Human leukocyte antigen I and levels of expression of antigen-presenting element proteins plays a role in triple negative breast cancer [PDF]

, 2019
Purpose: To determine the protein expression levels of leukocyte antigen I and antigen-presenting element (APM) genes, and to study their relationship with triple negative breast cancer (TNBC) in patients from Uyghur and Han, China.Methods ...
Baiketiyaer, Mukedaisi, Yujing, Zhang, Mushajiang, Munire, Xianglu, Zhu, Aikula, Gulizhareye   +4 more
core   +1 more source