Results 91 to 100 of about 22,575,443 (355)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Literary Exposures for an Ecological Age [PDF]
, 2017 This paper argues that exposures through literature to human fragility and vulnerability, which are default modes of life within the relational collective on-page, rehearse critical engagements for life off-page during a time of climate ...
Call, Christy
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Sarcopenia and aspartic acid magnesium
Journal of Physical Fitness and Sports Medicine, 2015 Sarcopenia from aging, inactivity, weightlessness, disease and malnutrition causes social problems due to associated physical dysfunction, a decrease in QOL, and risk of death.
Shigeru Yamada +4 more
doaj +1 more source
The Child to Come: Life After the Human Catastrophe by Rebekah Sheldon [PDF]
, 2017 Review of Rebekah Sheldon\u27s The Child to Come: Life after the Human ...
Tebokkel, Nathan
core +1 more source
Neurodiversity, epistemic injustice, and the good human life
Journal of Social Philosophy, 2022 R. Chapman, H. Carel
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
CIVIC LIFE: Evidence Base for the Triennial Review [PDF]
, 2010 This document forms part of the Equality and Human Rights Commission triennial review and covers equalities in civic life. It examines equality in political participation, freedom of language and freedom of worship.
Cutts, D +5 more
core
Sustainable Wearables: Wearable Technology for Enhancing the Quality of Human Life
, 2016 This paper aims to elicit insights about sustainable wearables by investigating recent advancements in wearable technology and their applications. Wearable technology has advanced considerably from a technical perspective, but it has stagnated due to ...
Jaewoon Lee +3 more
semanticscholar +1 more source