Results 111 to 120 of about 22,575,443 (355)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Value of Human Life a Divine Right in the Judicial European Space Pros and Cons of Euthanasia
EIRP Proceedings, 2020 Respect fullness for every person’s right to life and human dignity can be found in most of the great religions and ideologies throughout the world.
Ana Alina Ionescu Dumitrache +1 more
doaj
Chemical analysis of substitute drugs of abuse – “legal highs” from Lubuskie province, Poland
Journal of Medical Science, 2014 Introduction. Interest in substitute drugs of abuse, commonly called “dopalacze” [literally “after-burns”] that is “legal highs”, in Poland and abuse of such products, which could pose a significant life hazard, led to legislative action taken by the ...
Kinga Mruczyk +4 more
doaj +1 more source
Interpreting human life by looking the other way: Bonhoeffer on human beings and other animals [PDF]
, 2010 This is the author's pdf version of the book ...
Clough, David
core
Environmental impact of estrogens on human, animal and plant life: A critical review.
Environment International, 2017 BACKGROUND Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and ...
Muhammad Adeel +4 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Turing Test, Chinese Room Argument, Symbol Grounding Problem. Meanings in Artificial Agents [PDF]
, 2012 The Turing Test (TT), the Chinese Room Argument (CRA), and the Symbol Grounding Problem (SGP) are about the question “can machines think?”. We propose to look at that question through the capability for Artificial Agents (AAs) to generate meaningful ...
Menant, Mr Christophe
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
BMC Research Notes, 2018 Objectives In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how differences between tissue types might ...
Sally Chappell +6 more
doaj +1 more source