Results 81 to 90 of about 3,474,590 (264)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Medicine and the humanities – doctors as artists
South African Medical Journal, 2014 While only some can claim to be physician/artists, like neurosurgeon Roger Melvill whose paintings featured frequently on the covers of CME, we can surely all claim to be physician/connoisseurs of the arts. This piece is sparked by the art of Dorothy Kay, an acclaimed portrait painter, whose paintings of surgeons and anaesthetists at work in Port ...
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Human hair as a diagnostic tool in medicine
Biochemistry and Biophysics ReportsHair analysis has been used in the past as a method to explore environmental exposure to chemicals, toxins or drug ingestion, with wide applications in forensic science, environmental studies, anthropology and medicine. Although not a conventional sample
Venetia A. Florou +6 more
doaj +1 more source
Editorial of Special Issue "Hyaluronic Acid in Human Medicine". [PDF]
Biomolecules, 2022 Suchánek J.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A review of frailty instruments in human medicine and proposal of a frailty instrument for dogs. [PDF]
Front Vet Sci, 2023 Melvin RL +5 more
europepmc +1 more source