Results 271 to 280 of about 1,389,274 (311)

Ethacizin Metabolism in Humans

Xenobiotica, 1989
1. The major metabolites of ethacizin (ethyl 10-[3-diethylaminopropionyl]phenothiazine-2-carbamate) have been isolated from human urine by h.p.l.c. and identified by determination of u.v., i.r., n.m.r. and mass spectra and comparison with spectra of synthetic standard compounds. 2.
V L, Beloborodov, A P, Rodionov, N A, Tyukavkina, A V, Klimov, N V, Kaverina, , Kolesnik YuA, A N, Gritsenko, V P, Lesina   +7 more
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Human Pyrimidine Metabolism

JAMA: The Journal of the American Medical Association, 1966
Studies of pyrimidine metabolism in man have assumed interest in recent years with the recognition of specific alterations in their synthesis and excretion in certain diseases. Further, several pyrimidine antimetabolites have been introduced into cancer chemotherapy, and the metabolic alterations produced by some of these, 6-azauridine, has been a ...
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Metabolism of flumecinol in humans

Xenobiotica, 1987
1. The metabolism of 14C-flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol) was studied in volunteers after a single oral dose of 100 mg (11.1 MBq; 300 microCi). Radioactivity excreted in urine was 78.8 +/- 6.0% of dose and in faeces was 12.0 +/- 5.3% dose in 120 h. 2.
I, Klebovich, L, Vereczkey, E, Tóth, J, Tamás, M, Mák, G, Jalsovszky, S, Holly   +6 more
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Metabolism of chlorpromazine in humans

Biochemical Pharmacology, 1963
Abstract The isolation and characterisation of chlorpromazine metabolites from the urine of psychiatric patients is described. It is shown that chlorpromazine and its mono-and di-demethlated derivatives are hydroxylated and that these hydroxy compounds are conjugated mainly with glucuronic acid and, to a lesser extent, with sulphate.
A H, BECKETT, M A, BEAVEN, A E, ROBINSON
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Metabolic heterogeneity in humans

Cell
Recent advancements in technology, especially the emergence of single-cell technologies, genomic sequencing, metabolomics, and artificial intelligence, have enabled us to understand the distinct metabolic changes in different cell types, tissues, genders, disease states, ages, and populations.
Heather, Christofk, Christian, Metallo, Guanghui, Liu, Joshua, Rabinowitz, Lauren, Sparks, David, James   +5 more
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Folate metabolism in humans

American Journal of Medical Genetics, 1984
AbstractSeveral lines of evidence have linked flate metabolism to the expression of the fragile site at Xq27. Sutherland (1979) observed that expression of this marker depends on the composition of the culture medium and that deficiency of folic acid and thymidine promotes expression of the fragile site in lumphocytes, as does the addition of ...
Richard W. Erbe, Jin‐Chen C. Wang, John M. Opitz   +2 more
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Dehydroepiandrosterone Metabolism in Human Plasma

Hormone and Metabolic Research, 2003
The possibility that dehydroepiandrosterone (DHEA) is metabolized in human plasma was studied by column and thin-layer chromatography. The results obtained indicate that a time-dependent disappearance of DHEA is matched by the appearance of newly-formed species that may represent DHEA conversion by-products. Neither disappearance of DHEA, nor formation
Albo, F, BARBACCIA, MARIA LUISA, CAVAZZA, ANTONELLA, MARINI, MARIO, RODA, LUIGI GIORGIO   +4 more
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Metabolism of Progesterone in Human Myometrium

Endocrinology, 1969
In vitro incubation experiments with human myometrium collected during the proliferative phase of the ovarian cycle demonstrate progesterone-4-14C to be metabolized to 5 products, namely, pregn-4-en-20α-ol-3-one, 5α-pregnan-3,20-dione, pregn-4-en,6β-ol-3,20-dione, 5α-pregnan-20α-ol-3-one, and an unidentified product. The rate of progesterone metabolism
M J, Bryson, M L, Sweat
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Pharmacogenetics of Tolbutamide Metabolism in Humans

Diabetes, 1978
This study was designed to focus on the genetic control of tolbutamide disposition in humans and to provide insight into the potential for high accrued blood levels in individuals receiving fixed dosage regimens. Tolbutamide was administered intravenously to 42 nondiabetic subjects, eight of their relatives, and to five sets of twins.
J, Scott, P L, Poffenbarger
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Human Placental Oxygen Metabolism

1992
The highly-vascularized capillary network of the human placenta provides an adequate structure for gaseous exchange between foetal and maternal circulations, although it may not be the most efficient such structure. By comparison with other mammals, it has been suggested that guinea pigs, rats and rabbits may provide better conditions for growth in ...
Maguire, D. J., Voroteliak, V., Cowley, D., Cannell, G. R.   +3 more
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