Results 81 to 90 of about 9,306,580 (247)

Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein

bioRxiv, 2021
Human metapneumovirus (hMPV) is an important cause of viral respiratory disease. In this paper, we report the X-ray crystal structure of the hMPV fusion (F) protein in the postfusion conformation from genotype B.
Jiachen Huang, Pradeep Chopra, Lin Liu, T. Nagy, J. Murray, R. Tripp, G. Boons, J. Mousa   +7 more
semanticscholar   +1 more source

Detection of Respiratory Syncytial Virus and Human Metapneumovirus in Children with Respiratory Tract Infection by Use Real Time Polymerase Chain Reaction

Diyala Journal of Medicine, 2018
  Background: Respiratory tract illness is a major cause of morbidity and mortality among children, elderly and immunocompromised patients worldwide.
Hala Luay Abduljabbar, Areej Atiyah Hussein, Iman M Aufi, Qasim Sharhan Al-Mayah   +3 more
doaj   +2 more sources

The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Alfaraj, Sarah H., Altwaijri, Talal A., Alzahrani, Nojoom A., Memish, Ziad A.   +4 more
core   +1 more source

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

Nature Communications
The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen for an efficacious vaccine against hMPV respiratory infections.
M. Bakkers, Tina Ritschel, Machteld Tiemessen, Jacobus Dijkman, Angelo A Zuffianò, Xiaodi Yu, Daan van Overveld, L. Le, R. Voorzaat, Marlies M van Haaren, Martijn de Man, S. Tamara, L. van der Fits, R. Zahn, J. Juraszek, Johannes P. M. Langedijk   +15 more
semanticscholar   +1 more source

Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study

The Lancet Microbe, 2023
Background Respiratory disease is a major cause of morbidity and mortality; however, surveillance for circulating respiratory viruses is passive and biased.
A. Boehm, B. Hughes, Dorothea H Duong, V. Chan-Herur, A. Buchman, M. Wolfe, B. White   +6 more
semanticscholar   +1 more source

Application of Metagenomic Next‐Generation Sequencing in the Diagnosis of Pneumonia in Patients With Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background With the development of new sequencing technologies, metagenomic next‐generation sequencing (mNGS) has become a diagnostic tool for respiratory tract infections. Patients with cancer may develop pneumonia caused by infections or antitumor therapy.
Rong Qin, Chao Wang, Minghua Cong, Le Tian, Ning Li   +4 more
wiley   +1 more source

HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease. [PDF]

, 2008
Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop.
Allan Gould, Dekun Chen, Jacqueline Kattenbelt, Melanie Barnes, Michael Mather, Oscar Haigh, Robert R. Tindle, Scott Thomson   +7 more
core   +1 more source

Assessment of Illness Severity in Adults Hospitalized With Acute Respiratory Tract Infection due to Influenza, Respiratory Syncytial Virus, or Human Metapneumovirus

Influenza and Other Respiratory Viruses
Influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) are common respiratory viruses causing similar symptoms. Optimal tools to assess illness severity for these viruses have not been defined.
A. Falsey, E. Walsh, Stacey L. House, Yannick Vandendijck, M. Stevens, Eric K H Chan, G. Ispas   +6 more
semanticscholar   +1 more source

An Amplicon-Based Approach for the Whole-Genome Sequencing of Human Metapneumovirus

Viruses, 2021
Human metapneumovirus (HMPV) is an important cause of upper and lower respiratory tract disease in individuals of all ages. It is estimated that most individuals will be infected by HMPV by the age of five years old. Despite this burden of disease, there
R. Tulloch, J. Kok, I. Carter, D. Dwyer, John-Sebastian Eden   +4 more
semanticscholar   +1 more source

Human Metapneumovirus: A Neglected Contributor to Acute Respiratory Infections in Bangladesh: A Public Health Perspective

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Acute respiratory tract infections (ARTIs) are a primary cause of mortality in Bangladesh, yet the Human Metapneumovirus (hMPV) remains critically underdiagnosed. This perspective aims to evaluate the current diagnostic landscape, identify specific surveillance gaps, and propose a prioritized strategic framework for ...
Abdullaha Al Mamun, K. A. M. Inzamul Islam   +1 more
wiley   +1 more source