Recent Molecular Evolution of Human Metapneumovirus (HMPV): Subdivision of HMPV A2b Strains [PDF]
Microorganisms, 2020 Human metapneumovirus (HMPV) is a major etiological agent of acute respiratory infections in humans. HMPV has been circulating worldwide for more than six decades and is currently divided into five agreed-upon subtypes: A1, A2a, A2b, B1, and B2. Recently,
Naganori Nao +7 more
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A Review of Respiratory Infection Caused by the Human Metapneumovirus: Occurrence, Epidemiology, Pathogenesis, Public Health Outcomes, and Intervention Strategies. [PDF]
Health Sci RepABSTRACT Background and Aims Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infections, particularly in children, older adults, and individuals with immunocompromising conditions. Despite increasing global recognition of its clinical relevance, a comprehensive understanding of hMPV's epidemiology, pathogenesis, and ...
Izah SC, Ogwu MC.
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Viruses, 2020 Recent high-throughput sequencing revealed that only 2% of the transcribed human genome codes for proteins, while the majority of transcriptional products are non-coding RNAs (ncRNAs).
Wenzhe Wu +4 more
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Structural basis for childhood antibody recognition of the human metapneumovirus fusion protein [PDF]
Nature CommunicationsHuman metapneumovirus (hMPV) is a significant cause of acute respiratory illness in children and older adults, with most children becoming seropositive by five years of age.
Ahmed Magdy Khalil +7 more
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Cardio-Renal Diseases Are Independent Risk Factors of Severe Human Metapneumovirus Infection Among Patients Without Chronic Airway Diseases. [PDF]
J Med VirolABSTRACT Human metapneumovirus (hMPV) causes mild and self‐limiting disease in adults. However, the risk factors for serious adverse outcomes following hMPV infection in adult patients without preexisting chronic airway diseases remain poorly understood.
Kwok WC +8 more
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HMPV Virus Outbreak: First Review in Literature
Journal of Pharmacy and Bioallied SciencesHuman metapneumovirus (HMPV), a pathogen within the Pneumoviridae family, is a notable contributor to respiratory tract infections worldwide. Identified in 2001, HMPV predominantly affects young children, the elderly, and individuals with compromised ...
Sonia Dubey +7 more
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Intranasal bovine/human parainfluenza virus 3 vaccine candidates expressing human metapneumovirus wild-type or pre-fusion F protein elicit protective immunity against human metapneumovirus in hamsters [PDF]
Journal of VirologyHuman metapneumovirus (HMPV) and human parainfluenza virus 3 (HPIV3) are among the leading causes of severe pediatric respiratory illness worldwide, and there are no licensed vaccines.
Sirle Saul +9 more
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Probenecid Inhibits Human Metapneumovirus (HMPV) Replication In Vitro and in BALB/c Mice
VirusesHuman metapneumovirus (HMPV) is an important cause of acute respiratory tract infection and causes significant morbidity and mortality. There is no specific antiviral drug to treat HMPV or vaccine to prevent HMPV.
Harrison C. Bergeron +4 more
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Emergence and epidemiology of dominant variants of human metapneumovirus in the United States between 2016 and 2021 [PDF]
mBioHuman metapneumovirus (HMPV) causes acute respiratory disease worldwide and is the second leading cause of lower respiratory infection and hospitalization in young children in the USA. There is no licensed vaccine or therapeutic.
Lora Lee Pless +15 more
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The Clinical Respiratory JournalIntroduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious ...
David Chun‐Ern Ng +12 more
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