Host Components That Modulate the Disease Caused by hMPV [PDF]
Viruses, 2021 Human metapneumovirus (hMPV) is one of the main pathogens responsible for acute respiratory infections in children up to 5 years of age, contributing substantially to health burden. The worldwide economic and social impact of this virus is significant and must be addressed.
Nicolás M. S. Gálvez +7 more
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Viruses associated with pneumonia in adults. [PDF]
, 2012 Viral pneumonia, which is typically associated with disease in childhood, is increasingly recognized as causing problems in adults. Certain viruses, such as influenza virus, can attack fully immunocompetent adults, but many viruses take advantage of more-
Cesario, Thomas C
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Antibody recognition of the Pneumovirus fusion protein trimer interface.
PLoS Pathogens, 2020 Human metapneumovirus (hMPV) is a leading cause of viral respiratory infection in children, and can cause severe lower respiratory tract infection in infants, the elderly, and immunocompromised patients.
Jiachen Huang +2 more
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Virology Journal, 2021 Background Acute respiratory tract infections (ARTIs) causes high amounts of morbidity and mortality worldwide every year. Human metapneumovirus (HMPV) is a major pathogen of ARTIs in children.
Chao Wang +8 more
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Human Metapneumovirus (HMPV) Binding and Infection Are Mediated by Interactions between the HMPV Fusion Protein and Heparan Sulfate [PDF]
Journal of Virology, 2012 ABSTRACT Human metapneumovirus (HMPV) is a major worldwide respiratory pathogen that causes acute upper and lower respiratory tract disease. The mechanism by which this virus recognizes and gains access to its target cell is still largely unknown.
Andres, Chang +3 more
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Human metapneumovirus (hMPV): a re-emerging respiratory threat – transmission, clinical features, complications and management [PDF]
Infectious Diseases and Tropical MedicineHuman metapneumovirus (hMPV) is a globally prevalent yet underrecognized respiratory pathogen that disproportionately affects high-risk populations. Between 2024 and January 2025, numerous hMPV clinical cases were recorded in China, India, and other ...
S. Aishath +3 more
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Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system [PDF]
, 2018 Indexación: Scopus.This work was supported by Comisión Nacional de Investigación Científica y Tecnolígica (CONICYT) N◦21151028 and FONDECYT (N◦1070352 and N◦1170964) and the Millennium Institute on Immunology and Immunotherapy (P09/016-F).Human ...
Benavente, F.M. +8 more
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The human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro. [PDF]
PLoS ONE, 2011 Each year, during winter months, human Metapneumovirus (hMPV) is associated with epidemics of bronchiolitis resulting in the hospitalization of many infants.
Audrey Bagnaud-Baule +8 more
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Adjuvant effect of the human metapneumovirus (HMPV) matrix protein in HMPV subunit vaccines
Journal of General Virology, 2015 The human metapneumovirus (HMPV) fusion (F) protein is the most immunodominant protein, yet subunit vaccines containing only this protein do not confer complete protection. The HMPV matrix (M) protein induces the maturation of antigen-presenting cells in vitro.
Aerts, Laetitia +6 more
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Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state [PDF]
, 2017 Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection.
Chen, Man +13 more
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